Objective To analyze the spectrum of diseases in the emergency internal medicine department of Lhasa People's Hos-pital from 2020 to 2022.Methods Retrospective analysis was used to analyze the disease spectrum of all patients in the emergency department of our hospital in recent 3 years.Results A total of 15793 cases were included,including 5331(33.8)%in 2020,3813(24.1)%in 2021 and 6649(42.1)%in 2022.There were 8221 males and 7572 females,with a male to female ratio of 1.08:1.There were 7173 patients(45.40%)aged 15-39 years.74 patients(0.50%)aged ≥90 years;The top 3 cases in emergency internal medicine were digestive diseases(30.67%),respiratory diseases(25.89%)and circulatory diseases(10.46%).Among the single diseases,the proportion of plateau specific acute mountain sickness in 2020,2021 and 2022 was 10.2%,12.0%and 12.9%,respectively.Conclu-sions The number of patients treated in Lhasa People's Hospital in the three years from 2020 to 2022 was roughly equal;The top three cases in emergency medicine were digestive system,respiratory system and circulatory system.Most of the patients were male,and the age was 15-39 years old.Among them,the proportion of acute mountain sickness,which is unique to plateau,is increasing year by year.