急性冠脉综合征患者血清氮末端脑钠尿肽原水平与冠脉病变程度的关系
Association between serum NT-proBNP levels and severity of coronary artery lesions in patients with acute coronary syndromes
王爱萍 1张焕轶 1杨曙光 2吴云 1王咏梅 1张代民2
作者信息
- 1. 泰安市中心医院心内科,山东泰安271000
- 2. 解放军第88医院心内科,山东泰安271000
- 折叠
摘要
目的:探讨急性冠脉综合征( ACS)患者血清氮末端脑钠尿肽原(NT-proBNP)水平与冠脉病变程度之间的关系.方法:对150例因胸痛入院的患者行选样性冠状动脉造影,其中ACS组78例,稳定型心绞痛(SAP)组33例,冠状动脉造影正常组39例,采用冠状动脉造影Gensini积分评价冠状动脉病变的严重程度,同期测定患者血清NT-proBNP及左室射血分数(LVEF),分析NT-proBNP基线水平与LVEF及Gensini积分的关系.结果:①ACS组NT-proBNP浓度明显高于SAP组与正常组(均P＜0.05).SAP组NT-proBNP浓度明显高于正常组(P＜0.05).②ACS患者NT-proBNP水平与Gensini积分呈正相关(Pearson偏相关系数r=0.84,P ＜0.01).③多元逐步回归结果显示,ACS患者,影响NT-proBNP浓度的因素为冠状动脉造影积分和LVEF(冠状动脉造影Gensini积分的偏决定系数R2=0.8327,P＜0.01；LVEF的偏决定系数R2 =0.0034,P＞0.05).结论:ACS患者血清NT-proBNP水平与冠脉病变程度高度相关.
Abstract
ATM: To investigate the association between serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and the severity of coronary artery lesions. METHODS; Serum NT-proBNP concentrations and left ventricular ejection fraction (LVEF) were measured in 150 patients with chest pain. All patients underwent coronary artery angiography (CAG). Severity of coronary artery lesions was estimated by coronary angiographic Gensini score. According to clinical data and results of CAG, 78 patients were diagnosed with ACS, 33 patients were diagnosed with stable angina (SA) and 39 patients were normal controls. Correlations of NT-proRNP levels with LVEF and Gensini score were analyzed, RESULTS; Serum NT-proBNP concentrations were higher in ACS patients than those in SA patients and control subjects ( P < 0. 05 , respectively). A significant difference was observed in NT-proBNP levels between SA patients and control subjects (P<0. 05). NT-proBNP levels were correlated with the Gensini score in ACS ( r = 0. 83953 , P = 0. 0001 ) patients. Multiple stepwise regression analyses revealed that initial NT-proBNP levels were correlated with LVEF and Gensini score in ACS patients. Partial R2 of LVEF and Gensini score in ACS patients was, respectively, R2 =0. 8327 (P = 0. 0001) and R2 =0,0034 (P=0. 1035). NT-proBNP concentrations increased with the severity of coronary artery lesions in ACS group. CONCLUSION; Serum NT-proBNP level is correlated with the severity of coronary artery lesions and has significant prognostic value in ACS patients.
关键词
急性冠脉综合征/氯末端脑钠尿肽原/左室射血分数/冠状动脉造影/冠脉病变Key words
acute coronary syndromes/serum NT-proBNP/LVEF/coronary artery angiography/coronary artery lesions引用本文复制引用
出版年
2011
NETL
NSTL
维普
万方数据