槲皮素通过抑制ACE2治疗SARS-CoV-2所致心肌损伤的研究进展
Research progress of quercetin inhibiting ACE2 in the treatment of myocardial injury caused by SARS-CoV-2
万敬强 1郭振东 1马永霞 1谢萍2
作者信息
- 1. 甘肃省中医院心血管病一科,甘肃兰州 730000
- 2. 甘肃省人民医院心内一科,甘肃兰州 730000
- 折叠
摘要
2019 年底,由重症急性呼吸道综合征冠状病毒 2(SARS-CoV-2)引起的新型冠状病毒病肺炎(COVID-19)在全球迅速蔓延,由于其潜伏期长、传播性强、突变率高,因此,COVID-19 的防治已成为全球卫生领域的焦点问题.由于人体呼吸道黏膜表面血管紧张素转换酶 2(angiotensin converting enzyme 2,ACE2)含量丰富,而SARS-CoV-2表面的刺突蛋白(S蛋白)具有介导受体识别和结合功能,其受体结构域可特异性结合ACE2的肽酶结构域.因此,ACE2 是作为SARS-CoV-2 感染的宿主的途径,在SARS-CoV-2 感染机体过程中发挥至关重要的作用.与此同时,心肌组织ACE2 含量较丰富,且COVID-19 合并心肌损伤患者心肌组织ACE2 呈现表达异常.而我国传统中医药六大处方防治COVID-19 疗效显著,其中,共有中药单体成分槲皮素备受关注,防治机制可能与槲皮素抑制ACE2 密切相关.迄今为止,少有SARS-CoV-2 所致心肌损伤药物治疗的相关报道.因此,本文旨在通过文献汇总和生信预测探讨槲皮素是否通过抑制ACE2 在心肌组织中的高表达从而改善COVID-19 所致心肌损伤,从而降低COVID-19患者心源性死亡率及心血管并发症.
Abstract
At the end of 2019,coronavirus disease 2019(COVID-19)caused by severe acute respiratory SARS coronavirus 2(SARS-CoV-2)spread rapidly around the world.Due to the rich content of angiotensin converting enzyme 2(ACE2)on the mucosal surface of human respiratory tract,and the spike protein(S protein)on the surface of SARS-COV-2 has the function of inducing receptor recognition and binding,Receptor binding domains can specifically bind peptidase domains of ACE2.Thus,ACE2 acts as a host pathway for SARS-COV-2 infection and plays a crucial role in sarS-COV-2 infection.At the same time,the myocardial tissue ACE2 content is abundant,therefore,the myocardial tissue of patients with COVID-19 combined with myocardial injury shows abnormal expression of ACE2.The six major prescriptions of traditional Chinese medicine have remarkable effects in the prevention and treatment of COVID-19.Among them,quercetin,a monomer component of traditional Chinese medicine,has attracted more attention,and the prevention and treatment mechanism may be closely related to the inhibition of ACE2 by quercetin.Up to date,there have been few reports on drug therapy for myocardial injury caused by SARS-CoV-2..Therefore,this paper aims to explore whether quercetin can improve myocardial injury caused by COVID-19 by inhibiting the high expression of ACE2 in myocardial tissue through literature summary and bioinformatics prediction,thereby reducing Vascular complications and cardiac mortality in patients with COVID-19.
关键词
槲皮素/SARS-CoV-2/ACE2/COVID-19/心肌损伤Key words
quercetin/SARS-CoV-2/ACE2/COVID-19/myocardial injury引用本文复制引用
基金项目
国家自然科学基金地区科学基金(GZK-2018-42)
甘肃省国际科技合作项目(2019-0204-GJC-0006)
兰州市人才创新创业项目(2018-RC-72)
甘肃中医药大学研究生创新基金(LCCX2021007)
出版年
2024
NETL
NSTL
万方数据