甘油三酯-葡萄糖指数与颈动脉结构和弹性功能关联性及中介效应
Analysis of association between triglyceride-glucose index and carotid artery structure and elastic function and mediating effect
屈飏 1胡伟 2张彬 2张曦 2邢长洋 2袁丽君2
作者信息
- 1. 空军军医大学唐都医院超声医学科,陕西西安 710038;西安医学院研究生院,陕西西安 710068
- 2. 空军军医大学唐都医院超声医学科,陕西西安 710038
- 折叠
摘要
目的 探讨一般成年人群甘油三酯-葡萄糖指数(triglyceride-glucose index,TyG)与颈动脉结构和弹性功能的关系.方法 选取 2021年 6月～2021年 12月期间在唐都医院进行年度体检的健康志愿者的临床超声资料,进行横断面研究,共纳入志愿者 594例.根据TyG指数水平的三分位数范围分为 3组:T1组(4.24±0.10),T2组(4.45±0.06),T3组(4.71±0.11),各组人数均为 198.通过多元线性模型估计TyG指数,颈动脉内中膜厚度(carotid intima-media thickness,CIMT)与脉搏波传导速度(pulse wave velocity,PWV)之间的关系.采用中介效应分析身体质量指数(body mass index,BMI)、血压、血糖和血脂指标在TyG指数与CIMT及PWV关联性中的中介作用.结果 随着TyG指数水平的升高,调查对象各项数据依组逐次变化,T1、T2与T3组吸烟的比例逐次升高并有统计学差异,相邻组及跨组比较均P<0.05;年龄、女性比例、BMI、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、空腹血糖、饮酒比例、CIMT与 PWV逐渐增高,高密度脂蛋白胆固醇逐渐减低,相邻组及跨组比较均P<0.01.多元线性回归分析发现,调整协变量后,TyG 指数每增加 1个单位,CIMT增加 0.54 μm(95%CI:0.13～0.64;P<0.01),PWV增加 0.28 m/s(95%CI:0.20～0.37;P<0.01).中介效应分析发现,SBP以间接介导的方式对PWV产生正向影响,其中介效应占比为 18.2%.结论 TyG指数是正常成年人群CIMT及PWV的独立危险因素.TyG指数通过SBP介导以间接方式与PWV呈正相关.
Abstract
AIM To investigate the relationship between triglyceride-glucose index(TyG)and carotid artery structure and elastic function in the general adult population.METHODS A cross-sectional study was conducted on clinical ultrasound data of healthy volunteers who underwent annual physical examinations at Tangdu Hospital from June 2021 to December 2021.A total of 594 volunteers were included.Volunteers were divided into three groups based on the interquartile range of TyG index levels:(4.24±0.10)for T1 group,(4.45±0.06)for T2 group,and(4.71±0.11)is T3 group.Estimate the relationship between TyG index,carotid intima media thickness(CIMT),and pulse wave velocity(PWV)using a multiple linear model.Using mediation analysis to examine the mediating roles of Body Mass Index(BMI),blood pressure,blood glucose,and lipid indicators in the association between TyG index and CIMT and PWV.RESULTS As the TyG index level increases,the various data of the survey subjects change gradually by group.The proportion of smoking in T1,T2,and T3 groups increases gradually and there is a statistical difference.Adjacent and cross group comparisons are all P<0.05;Age,proportion of females,BMI,total cholesterol,low-density lipoprotein cholesterol,triglycerides,fasting blood glucose,alcohol consumption,CIMT and PWV gradually increased,while high-density lipoprotein cholesterol gradually decreased.Adjacent and cross group comparisons were all P<0.01.Multiple linear regression analysis found that after adjusting for covariates,for every 1 unit increase in the TyG index,the CIMT increased by 0.54 μm(95%CI:0.13～0.64;P<0.01),PWV increased by 0.28 m/s(95%CI:0.20～0.37;P<0.01).The mediation effect analysis found that SBP has a positive impact on PWV indirectly mediated,with a mediation effect accounting for 18.2%.CONCLUSION TyG index is an independent risk factor for CIMT and PWV in the normal adult population.TyG index is positively associated with PWV in an indirect manner mediated by SBP.
关键词
甘油三酯-葡萄糖指数/超声/颈动脉内中膜厚度/脉搏波传导速度/中介效应分析Key words
triglyceride-glucose index/ultrasound/internal carotid intima-media thickness/pulse wave conduction velocity/mediation effect analysis引用本文复制引用
基金项目
陕西省重点研发计划-重点产业创新链(群)-社会发展领域(2023-ZDLSF-22)
唐都医院临床创新救治能力提升项目(2022TDLCTS04)
唐都医院临床创新救治能力提升项目(2022TDLCTS07)
出版年
2024
NETL
NSTL
万方数据