Pathogenic Surveillance on the Viral Diarrhea in Chengdu from 2021 to 2022
Objective To analyze the pathogenic monitoring results of viral diarrhea in Chengdu from 2021 to 2022,and to provide a basis for formulating scientific prevention and control measures.Methods Two hospitals in Chenghua District,Jinniu District,Jintang County and Pengzhou City were selected as monitoring sentinels.From April 2021,samples of patients with three or more defecations in 24 hours,accompanied by changes in stool characteristics(loose stool,watery stool,etc.),or vomiting twice in 24 hours were collected at each sentinel point,and pathogen monitoring was carried out.Surveillance viruses included Norovirus(NV)GⅠ,GⅡ,rotavirus(RV)A,B,C,human astro virus(AstV)Intestinal adenovirus(AdV),Zaru virus(SaV).Methods of Laboratory testing included fluorescence PCR,multi pathogen detection and conventional PCR detection.The pathogenic surveillance data of Enterovirus from 2021 to 2022 were analyzed.Statistical analysis was conducted by using SPSS 19.0 software,with counting data was described by using frequency and rate,and comparison among groups was tested by using Pearson x2 inspections,with an inspection level of α=0.05,bilateral test.Results The total positive rate of virus detected in samples of diarrhea/vomiting patients in Chengdu from 2021 to 2022 was 29.84％,with the highest positive rates of RVA,NVG Ⅱ,and AdV being 11.90％,9.26％,and 8.73％,respectively.The proportion of one virus type detected was 77.41％,while the proportion of two virus types detected at the same time was 16.90％.The proportion of three virus types detected at the same time was 4.52％,and the proportion of four virus types detected at the same time was 1.18％.The detection rate of diarrhea virus varies in different months,with the highest overall positive detection rate being 54.32％in February,and then showing a decreasing trend month by month.The positive rate of virus detection in male was 27.75％,while the positive rate of virus detection in female was 32.27％,with a statistically significant difference(x2=4.15,P=0.042).The positive rate of virus detection was 37.12％in children aged 5 and below,and 23.52％for those aged other years,with a statistically significant difference(x2=37.48,P＜0.001).Among all professions,preschool children,scattered children and students had the highest positive rates of virus detection,with 41.46％,36.32％,and 34.20％,respectively.Conclusions In recent two years,rotavirus,orovirus and enteroadenovirus are the dominant pathogens of viral diarrhea in Chengdu.It is suggested that the surveillance of these three Viroid should be strengthened in the future,and the targeted prevention and control measures should be carried out.
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