Investigation and analysis of the current situation of HCV and TP Co-infection HIV/AIDS patients in Renshou County 2053
Objective To analyze the co-infection of Hepatitis C Virus(HCV)and Treponema pallidum(TP)among HIV/AIDS patients in Renshou County,providing a foundation for the implementation of"comprehensive disease prevention"measures.Methods Serum samples from 2 053 HIV/AIDS patients who underwent HIV viral load testing in Renshou County from January to July 2023 were tested for HCV antibodies and TP antibodies using enzyme-linked immunosorbent assay,and TP antibody-positive samples were retested with the TRUST assay.SPSS 26.0 software was used for statistical analysis,and x2 test was used to compare rates.P＜0.05 was considered statistically significant.Results Among the 2053 HIV/AIDS patients,29 cases(1.4％)tested positive for HCV antibodies,445 cases(21.7％)tested positive for TP antibodies,241 cases(11.7％)tested positive for both TP antibodies and TRUST,14 cases(0.7％)were positive for both HCV antibodies and TP antibodies,and 5 cases(0.3％)were positive for HCV antibodies,TP antibodies,and TRUST.Statistically significant differences were observed in the HCV antibody and TP antibody plus TRUST positivity rates among different infection pathways(all P＜0.05).The highest prevalence of HCV antibody positivity was observed in individuals infected through intravenous drug use,while TP antibody+TRUST positivity was higher in individuals infected through heterosexual contact compared to homosexual contact.Statistically significant differences were observed among three groups of contact histories:non-marital commercial heterosexual contact,non-marital non-commercial heterosexual contact,and marital/stable partner contact(all P＜0.05).Malesshowed higher infection rates in non-marital commercial heterosexual contact,whereas females exhibited higher rates in non-marital non-commercial heterosexual contact and marital/stable partner contact compared to males.There were statistically significant differences in TP antibody positivity rates and TP antibody+TRUST positivity rates between different genders(all P＜0.05),with males having higher rates than females.Statistically significant differences were also observed in the positive rates of HCV antibodies among different age groups(P＜0.05),with the 31-50 age group showing higher rates than other age groups.Conclusions Renshou County's HIV/AIDS patients exhibit a certain degree of co-infection with HCV and TP,with a notably higher co-infection rate of syphilis.Therefore,it is essential to enhance HCV,TP,and related infection screening among the HIV/AIDS population,so as to provide a scientific basis for the diagnosis,treatment,and precise prevention and control of these diseases.
Human Immunodeficiency VirusHIV/AIDS patientshepatitis C Virustreponema pallidumco-infection
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