Analysis on surveillance results of inpatients with severe acute respiratory infection in a sentinel hospital of Chengdu from 2021 to 2022
Objective To investigate the pathogen spectrum of hospitalized patients with severe acute respiratory virus infection(SARI)in a sentinel hospital of Chengdu,Sichuan province,and to providing the basis for the diagnosis and treatment of influenza negative patients.Methods Throat swab samples of SARI cases from a sentinel hospital of Chengdu were collected from January 2021 to December 2022,and multiple respiratory pathogens were detected by multiplex fluorescent PCR.And the positive detection rate was compared between groups by Chi-square test(SPSS 26.0),the test level α=0.05.Results Out of 608 SARI samples collected,300 patients tested positive for respiratory pathogens,with a total positive rate of 49.34％.Of these,155 cases were positive for Haemophilus influenzae(25.49％),58 cases were positive for adenovirus(9.54％),45 cases were positive for influenza B virus(7.40％)and 32 cases were positive for influenza A virus(5.30％);72 cases wrer co-infected(12.0％).Influenza virus was concentrated in autumn and winter,and respiratory syncytial virus was mainly concentrated in spring.The positive rate of infection in different age groups was statistically significant(P＜0.001).The positive rate of infection in patients aged 5～17 years was the highest(80.23％),followed by those aged under 5 years(59.17％).Conclusions The main pathogens of SARI cases in Chengdu are haemophilus influenzae,influenza virus and adenovirus.Different monthly peaks of infection with different pathogens should be monitored for SARI patients in the age group under 18 years.Detection of multiple respiratory pathogens in SARI cases can not only help hospitals treat patients with respiratory pathogens of unknown etiology,but also play an important public health role in the prevention and management of SARI.
severe acute respiratory infectionpathogenic detectionmultiplex fluorescent PCR
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