2012-2021年成都市青羊区新报告HIV/AIDS病例首次CD4+T淋巴细胞检测及分析
Detection and analysis of first CD4+T lymphocyte test of newly reported HIV/AIDS cases in Qingyang District of Chengdu from 2012 to 2021
罗德维 1万思齐 1范贤晴 1宋怡 1徐小森 1郝晓颖 1廖亚男1
作者信息
- 1. 成都市青羊区疾病预防控制中心,成都 610041
- 折叠
摘要
目的 分析成都市青羊区2012-2021年新报告HIV/AIDS病例首次CD4+T淋巴细胞检测结果,探索其影响因素.方法 2012-2021年对成都市青羊区新报告HIV/AIDS病例且愿意配合者采集静脉血,使用单平台流式细胞术检测CD4+T淋巴细胞,所得资料采用SPSS 23.0软件进行单因素、多因素、x2检验和Spearman相关性分析,以P＜0.05为差异有统计学意义.结果 2012-2021年完成首次CD4+T淋巴细胞检测的病例1 479例,占可追踪到的新报告病例的94.93％(1 479/1 558),首次CD4+T淋巴细胞＜200个/μl 550例(37.19％),诊断后 14d内接受检测 1 145例(77.42％).各年份间晚发现率差异无统计学意义(x2=31.767,P=0.241),10年间检测及时性呈上升趋势(Rs=0.270,P＜0.001),多因素Logistic回归分析显示,年龄越大、户籍在本区、异性传播、来源于医疗机构的病例更容易发生晚发现(＜200个/μl)的情况.结论 2012-2021年成都市青羊区新报告HIV/AIDS病例首次CD4+T淋巴细胞检测比例较高,检测及时率逐年提升,但检测值无明显上升趋势,中度和重度免疫缺陷占比仍然较高.应继续宣传动员,扩大检测,早发现,早治疗,实现"治疗即预防"的策略.
Abstract
Objective To analyze the results of the first CD4+T lymphocyte test of newly reported HIV/AIDS cases in Qingyang District of Chengdu City from 2012 to 2021,and to explore its influencing factors.Methods From 2012 to 2021,venous blood was collected from newly reported HIV/AIDS cases in Qingyang District of Chengdu who where willing to cooperate.The first CD4+T lymphocyte was detected by single-platform flow cytometry and SPSS 23.0 software was used for univariate,multi-variate,x2 test and spearman correlation analysis.The difference P＜0.05 was considered statistically significant.Results A total of 1 479 cases finished the first CD4+T lymphocyte test from 2012 to 2021,it accounted for 94.93％of all newly reported cases that could be traced(1 479/1 558),the CD4+T lymphocyte less than 200 cells/μl(37.19％)counted of 550 patient for the first time.There were 1 145 cases received the CD4+T lymphocyte test within 14 days of diagnosis(77.42％).There was no significant difference in the late detection rate among different years(x2=31.767,P=0.241).The timeliness of test showed an upward trend in last 10 years(Rs=0.270,P＜0.001).The multivariate logistic regression analysis showed that the late detection rate was higher among the cases with older age,registered residence,heterosexual transmission and the cases from medical institutions(＜200/μl).Conclusions From 2012 to 2021,the proportion of the first time CD4+T lymphocytes increased in newly reported HIV/AIDS cases in Qingyang District.The timelines of test increased year by year,but the test value had no obvious upward trend.The proportion of moderate and severe immunodeficiency is still high.It is necessary to continue to strenthen publicity and mobilization,expand the detection area.Early detection and early treatment to implement the strategy of"treatment is prevention".
关键词
人类免疫缺陷病毒/新报告HIV/AIDS病例/CD4+T淋巴细胞Key words
human immunodeficiency virus/newly reported HIV/AIDS cases/CD4+T lymphocytes引用本文复制引用
出版年
2024
NETL
NSTL
万方数据