Analysis on drug resistance of mycobacterium tuberculosis in Deyang City from 2014 to 2022
Objective To investigate the drug resistance of Mycobacterium tuberculosis to first-line and second-line anti-tuberculosis drugs in Deyang City,to analyze the trend and characteristics of tuberculosis drug resistance in the city,and to provide reference for tuberculosis prevention and control management and clinical rational drug use.Methods The information of tuberculosis patients in Deyang City from 2014 to 2022 was collected and statistically analyzed.Mycobacterium strains isolated from sputum culture in tuberculosis laboratory of Deyang Center for Disease Control and Prevention from 2014 to 2022 were collected by proportional method.Sensitivity tests were conducted for four first-line anti-tuberculosis drugs(isoniazid INH,rifampicin RFP,streptomycin SM and ethambutol EMB)and two second-line anti-tuberculosis drugs(kanamycin KM and ofloxacin OFX).Strain identification was conducted at the same time.The experimental results were analyzed.The drug resistance rate was compared by x2 test,and P＜0.05 was considered statistically significant.Results A total of 1 229 strains were collected in Deyang City from 2014 to 2022,including 1 182 Mycobacterium tuberculosis(MTB)and 45 non-tuberculous Mycobacterium(NTM).The positive rate of NTM was 3.66％(45/1 229).The results of MTB drug sensitivity test showed that the total drug resistance rate was 21.66％(256/1 182),among which the drug resistance rate was 18.91％(198/1 047)in newly diagnosed patients and 42.96％(58/135)in revisiting patients.The total multidrug resistance(MDR)rate was 5.16％(61/1 182),among which the MDR rate was 3.92％(41/1047)in newly diagnosed patients and 14.81％(20/135)in revisiting patients.The annual drug resistance rates were 51.75％,27.33％,22.52％,13.38％,13.46％,14.14％,15.00％,17.12％and 24.44％from 2014 to 2022,respectively.The MDR rates were 11.40％,5.23％,7.95％,3.82％,3.85％,2.02％,2.50％,3.60％and 5.56％,respectively.The drug resistance rates of the four first-line anti-tuberculosis drugs,INH,RFP,SM and EMB,were 13.03％(154/1 182),6.26％(74/1 182),13.37％(158/1 182)and 2.62％(31/1 182),respectively.The drug resistance rates of the two second-line anti-tuberculosis drugs,KM and OFX,were 1.18％(14/1 182)and 4.23％(50/1 182),respectively.The rate of mono-drug resistance was 12.27(145/1 182),the rate of multi-drug resistance was 5.84％(69/1 182),and the rate of quasi-widespread drug resistance was 1.10％(13/1 182).Conclusions The drug resistance rate of Mycobacterium tuberculosis in Deyang City was high,and the multidrug resistance rate was higher than the average levels of Sichuan Province and Guangdong Province.In recent years,the drug resistance of tuberculosis had shown a rising trend.It is necessary to strengthen the screening and monitoring of tuberculosis drug resistance,strengthen the management of patients,and scientifically use drugs to control the spread of drug-resistant tuberculosis.
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