Survival analysis of injection drug users with HIV/AIDS after antiretroviral therapy in Yunnan Province from 2011 to 2022
Objective To analyze the survival status of HIV infected patients and AIDS patients who received antiviral therapy(ART)through intravenous drug abuse in Yunnan province,and to explore the influencing factors of survival time.Methods The data of HIV/AIDS patients receiving ART from 2011 to 2022 in Yunnan province were collected.SPSS 22.0 software was used for statistical analysis.The survival rate after ART was analyzed by life table method,and the survival time and influencing factors were analyzed by univariate and multivariate Cox proportional hazards regression models.Results A total of 9 849 HIV/AIDS patients receiving ART among intravenous drug users in Yunnan province from 2011 to 2022 were diagnosed.The cumulative survival rates before 1,3 and 5 years of correction were 94.62％、86.09％、79.24％,respectively.The cumulative survival rates were 94.02％、83.82％、76.22％,respectively.The mortality rate in the first five years after correction accounted for 78.86％(2 123/2 692)and 78.80％(2 464/3 127).The death rate of patients mainly concentrated in the first five years after ART initiation,and the death rate slowed down with the extension of treatment time,with the highest mortality in the first year.Cox regression model multivariate analysis showed that women had a lower risk of death than men(HR=0.568,95％CI:0.499-0.648).The risk of death in the age group＞45 years old was lower than that in the age group＜35 years old and 35-45 years old,respectively(HR=0.270,95％CI:0.238～0.307)、(HR=0.549,95％CI:0.487-0.618);The risk of death in the group with baseline CD4+T lymphocytes＜100/μl was higher than that in other CD4+T lymphocyte groups;People with baseline BMI＞25.0 kg/m2 and 18.5-25.0 kg/m2 had lower risk of death than those with baseline BMI＜18.5 kg/m2,respectively(HR=0.608,95％CI:0.497-0.743)、HR=0.774,95％CI:0.705-0.850),respectively.In terms of education,the middle school and above population had lower mortality risk than illiterate population(HR=0.516,95％CI:0.410-0.648).Conclusions For intravenous drug users,the case fatality rate is higher in the first five years of initiation of antiviral therapy,especially in the first year,and the risk of death is higher in males,patients under 35 years of age,abnormal haemoglobin indicators,divorced or widowed,and educated and illiterate.The risk of death was inversely correlated with baseline CD4+T lymphocyte count and baseline body mass index.This suggests that targeted health education and counselling should be provided to this population,and adherence education should be strengthened and the number of follow-up visits should be increased to reduce the risk of death and improve survival.
injection drug usersHIV/AIDSantiretroviral therapy(ART)survival analysis
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NSTL
万方数据
