Analysis on monitoring results of poliomyelitis antibody levels in different immunization programs in Chongqing from 2021 to 2022
Objective To evaluate the neutralizing antibody levels of poliomyelitis after different basic immunization schedules of poliomyelitis inactivated vaccine(IPV)and bivalent oral poliomyelitis live attenuated vaccine(bOPV)in Chongqing,and to provide basis for scientific evaluation of vaccine immune effect and timely adjustment of immunization strategy.Methods From October 2021 to October 2022,children of the appropriate age for primary polio immunization in four districts/counties in Chongqing were selected and tested for serum polio neutralizing antibodies 1-6 months after the completion of primary vaccination by two different vaccination schedules:3IPV and 2IPV+bOPV.Fisher's exact test and Wilcoxon rank sum test were used to compare the positive rates and the antibody titers of the neutralizing antibody,and the test level was α=0.05.Results From October 2021 to October 2022,the positive rates of type I antibody in the 2IPV+bOPV group and the 3IPV group were 99.46％and 100％,respectively(P=0.46),after the completion of primary polio immunization.The medians of antibody titer were 2 048 and 128,respectively(Z=-13.75,P＜0.001).The positive rates of type Ⅱ antibody were 99.83％and 100％,respectively(P=0.04),and the medians of antibody titer were 96 and 192,respectively(Z=-5.59,P＜0.001).The positive rates of type Ⅲ antibody were 99.46％and 99.55％,respectively(P=1.00),and the medians of antibody titer were 2 048 and 256,respectively(Z=-11.53,P＜0.001).Conclusions The typeⅡ antibody levels of the 3IPV group were higher than those of the 2IPV+bOPV group.To better reduce and prevent type Ⅱ vaccine-associated paralytic poliomyelitis(VAPP)and circulating vaccine-derived poliovirus(cVDPV2),the 3IPV immunization program is a better choice.
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