福州市1 073例HIV/AIDS患者抗病毒治疗效果及耐药情况分析
Analysis on effect of antiretroviral therapy and drug resistance for 1 073 AIDS/HIV patients in Fuzhou city
陈玲玲 1姚栩 1石蕾 1陈艳 1卢园1
作者信息
- 1. 福州市疾病预防控制中心检验科,福建 350004
- 折叠
摘要
目的 探讨福州市1 073例HIV/AIDS患者抗病毒治疗的效果和耐药情况,为进一步完善艾滋病抗病毒治疗提供依据.方法 采用回顾性调查方法,收集2019年1月-2020年12月在福州市接受抗病毒治疗的1 073例HIV/AIDS患者的资料,评价抗病毒治疗后患者的CD4+T淋巴细胞计数、病毒载量以及耐药情况,评价抗病毒治疗效果、免疫功能、抗病毒药物耐药情况.结果 1 073例HIV/AIDS患者中,抗病毒治疗后病毒完全抑制798例(74.37％),抗病毒治疗失败39例(3.63％).免疫功能正常411例(38.30％).CD4+T淋巴细胞计数和病毒载量存在负相关关系(rs=-0.166,P＜0.001).39例抗病毒治疗失败患者中,耐药发生率为20.51％(8/39),对核苷酸类反转录酶抑制剂(NR-TIs)和非核苷类反转录酶抑制剂(NNRTIs)的耐药发生率分别为15.38％(6/39)、17.95％(7/39),对NRTIs和NNRTIs的多重耐药发生率为12.82％(5/39).结论 福州市HIV/AIDS患者抗病毒治疗效果良好,耐药发生率总体较低.
Abstract
Objective To discuss the effect of antiretroviral therapy(ART)and drug resistance for 1 073 AIDS/HIV pa-tients in Fuzhou city,so as to provide reference for further improvement of AIDS antiretroviral therapy.Methods A retrospective survey was conducted to collect the data of 1 073 HIV/AIDS patients who received antiviral treatment in Fuzhou city from January 2019 to December 2020.The CD4+T lymphocyte count,viral load and drug resistance of the pa-tients after antiviral treatment were evaluated,and the antiviral treatment effect,immune function and drug resistance were evaluated.Results Among the 1 073 cases,complete viral suppression was achieved in 798 patients(74.37％)through antiviral treatment.Treatment failure was observed in 39 cases(3.63％).A total of 411 patients(38.30％)exhibited nor-mal immune function.The CD4+T lymphocyte count and viral load exhibit a negative correlation(r,=-0.166,P＜0.001).Among 39 patients who failed antiviral treatment,the incidence of drug resistance was 20.51％(8/39).The inci-dence of resistance to nucleotide reverse transcriptase inhibitors(NRTIs)and non nucleoside reverse transcriptase inhibi-tors(NNRTIs)was 15.38％(6/39)and 17.95％(7/39),respectively.The incidence of multidrug resistance to NRTIs and NNRTIs was 12.82％(5/39).Conclusion The antiretroviral therapy in Fuzhou city has shown good efficacy,with an overall low occurrence rate of drug resistance.
关键词
抗病毒治疗/病毒载量/CD4+T淋巴细胞/耐药Key words
Antiretroviral therapy/Virus load/CD4+T cells/Drug resistance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据