Analysis on influencing factors on disease severity of SARS-CoV-2 Omicron variant infected persons in Shandong province
Objective To explore the disease severity and influencing factors of SARS-CoV-2 Omicron variant patients,so as to provide scientific basis for targeted prevention and control measures.Methods Retrospectively collected and ana-lyzed the data of Omicron variant patients admitted to designated hospitals for COVID-19 in some cities of Shandong prov-ince from January 1 to May 30,2022,and clinical classification was performed according to disease severity.The differences in disease severity among infected persons of different ages,nucleic acid conversion times,hospitalization times,and vacci-nation doses were analyzed.Multivariate binary logistic regression was used to analyze the factors influencing the severity of disease in Omicron variant patients.Results A total of 573 Omicron variant patients were included,the clinical clas-sification included 315(55.0％)asymptomatic patients,214(37.3％)mild patients,44(7.7％)common patients,and 0(0％)severe patients.There were 397(69.3％)people have received booster vaccination,while 176(30.7％)people have not received booster vaccination.Among the 573 patients,83.6％(479/573)were concentrated in the 18-69 years old age group.There were significant differences in the severity of the disease among different age groups(x2=17.775,P＜0.01).There were significant differences in the severity of the disease in patients with different nucleic acid turning negative time(x2=13.693,P＜0.01).There was no significant differ-ence in asymptomatic infection and mild/common infection a-mong patients with different hospital stay(x2=3.331,P＞0.05).There was a significant difference in the severity of dis-ease between the booster group and the non-booster group(x2=6.267,P＜0.05).The results of multivariate binary logistic regression analysis showed that nucleic acid negative time of 8-14 days(OR=0.416,95％CI:0.243-0.712,P＜0.05)and vaccination booster(OR=0.588,95％CI:0.386-0.895,P＜0.05)were protective factors for Omicron variant patients.Conclusion The age of SARS-CoV-2 O-micron variant patients were mainly 18-69 years old,and the clinical classification was mainly asymptomatic patients,nu-cleic acid negative time and vaccination booster were the influencing factors of disease severity in patients.
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