山东省临沂市新报告≥50岁HIV/AIDS病例生存时间及影响因素分析
Analysis on survival time and influencing factors of newly reported HIV/AIDS cases aged 50 years and above in Linyi city
李莉 1王子夫 1王燕 1李印邦1
作者信息
- 1. 临沂市疾病预防控制中心艾滋病防制科,山东 276000
- 折叠
摘要
目的 分析山东省临沂市新报告≥50岁的艾滋病病毒感染者和艾滋病患者(HIV/AIDS)生存状况及其影响因素,为提高患者生存时间和优化防控措施提供依据.方法 采用回顾性队列研究方法,通过中国疾病预防控制信息系统艾滋病防治综合信息系统,收集截至2022年12月31日现住址在山东省临沂市的确诊时年龄≥50岁的HIV/AIDS病例,采用寿命表法描述生存状况,Cox比例风险模型分析生存时间的影响因素.结果 共350例HIV/AIDS病例纳入分析,其中HIV感染者210例(占60.00％)、AIDS患者140例(占40.00％).接受抗病毒治疗300例(85.71％).截至观察终点,存活265例,死亡85例,确诊阳性后第1、3、5、10年的累积生存率分别为78.04％、70.84％、64.04％、57.79％.多因素Cox回归分析结果显示,已婚有配偶(HR=0.478,95％CI:0.268～0.850,P＜0.05)、初中学历(HR=0.344,95％CI:0.161～0.733,P＜0.05)、已接受抗病毒治疗(HR=0.142,95％CI:0.066～0.308,P＜0.05)和首次 CD4 细胞计数 200～349 个/μL(HR=0.381,95％CI:0.185～0.784,P＜0.05)、首次 CD4 细胞计数 350～499 个/μL(HR=0227,95％CI:0.092～0.561,P＜0.05)、首次 CD4 细胞计数≥ 500 个/μL(HR=0.359,95％CI:0.143～0.901,P＜0.05)的病例死亡风险相对较低.结论 临沂市≥50岁HIV/AIDS病例的生存率有待提高,婚姻状况、文化程度、是否接受抗病毒治疗和首次CD4细胞计数是该人群生存时间的影响因素.
Abstract
Objective To analyze the survival time and influencing factors of newly reported HIV/AIDS cases aged 50 years and above in Linyi city,so as to provide evidence for improve the survival time and optimize the prevention and con-trol measures.Methods A retrospective cohort study was conducted to analyze the data of HIV/AIDS cases who lived in Linyi city aged 50 years and above before December 31th,2022.Data was collected from Chinese HIV/AIDS Basic Information Management System.Life table method was applied to describe the survival status,and influencing factors of survival time were analyzed by Cox proportional regression model.Results Of the 350 HIV/AIDS cases,210 were HIV(60.00％)and 300 received antiretroviral therapy(ART).At the end point of observation,265 cases were survived and 85 cases were died.The cumulative survival rate of 1 year,3 years,5 years and 10 years after diagnosis was 78.04％,70.84％,64.04％and 57.79％.Cox multivariate analysis showed that those married(HR=0.478,95％CI:0.268-0.850,P＜0.05),with junior middle school education level(HR=0.344,95％CI:0.161-0.733,P＜0.05),received ART(HR=0.142,95％CI:0.066-0.308,P＜0.05),and the first CD4+T cell counts in 200-349(HR=0.381,95％CI:0.185-0.784,P＜0.05),350-499(HR=0.227,95％CI:0.092-0.561,P＜0.05)and ≥500 cells/μL(HR=0.359,95％CI:0.143-0.901,P＜0.05)could reduce the risk of death.Conclusion Survival of HIV/AIDS cases ≥50 years of age in Linyi city needs to be improved,with marital status,literacy,receipt of antiretroviral therapy,and first CD4 cell counts as influencing factors for survival time in this population.
关键词
艾滋病/人类免疫缺陷病毒/生存分析/影响因素Key words
Acquired immune deficiency syndrome/Human immunodeficiency virus/Survival time/Influencing factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据