Preparation and properties analysis of Capecitabine-LDHs nanocomplexes
Objective To prepare sodium alginate(SA)coated capecitabine-layered bimetallic hydroxide(LDHs)nano-composites to form microspheres,and to analyze their properties.Methods Capecitabine-LDH nanocomplexes were synthesized via the co-precipitation method.The content of capecitabine in the capecitabine-LDH/SA nanocomposites was determined using a UV-spectrophotometer.The crystal structures of LDHs and capecitabine-LDHs nanocomplexes were analyzed by X-ray diffractometer,and the release rate of capecitabine was determined.Results The SA microspheres were transparent adhesive.The SA/LDHs microspheres were milky white spheres.The surface morphology of the micro-sphere was observed by 30-fold scanning electron microscope(SEM).The surface morphology of microspheres observed by 1000-fold SEM showed that the structure of microspheres changed after LDHs was added,and the lamellar structure of LDHs could be clearly seen.Capecitabine-SA/LDHs nanohybrid microspheres and SA/LDHs microspheres had the char-acterwastics of LDHs and SA microspheres.LDHs/SA had an obvious peak at peak 003(11.59°),and the characterwastic peaks of SA(31.38°,45.57°)were more obvious.Release of capecitabine in buffer solution with pH=7.2 at 37 ℃.the first 100 min of release of the microspheres was the rapid release stage of capecitabine in capecitabine-SA/LDHs nanohy-brid microspheres,and the release rate reached 80％.In the following 200 minutes,capecitabine release completed the slow release phase,and the release rate reached 95％.The fast release time of the nano-hybrid without SA coating was 50 min,the release rate was 67％,and the release rate was 80％within 100 min,and the release was incomplete.Release of capecit-abine in a pH=2.2 buffer solution at 37℃:the release rate of capecitabine-LDHS nanohybrid reached 98％within 30 min and was completely released within 50 min.The sustained release performance of the drug in capecitabine-SA/LDHs na-nohybrid microspheres was better than that of physical mixture of LDHs and capecitabine.The first 100 min of capecitabine re-lease in the microsphere was the rapid release stage,the release rate reached 90％,and the slow release stage was completed in the following 230 min,the release rate reached 98％,and then the equilibrium was reached,and capecitabine was completely released.Conclusion Under certain conditions,capecitabine-sodium alginate/LDHs microspheres can control the slow release rate of capecitabine under acidic conditions.
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