Diabetic kidney disease(DKD)is one of the main causes of chronic renal failure in China,and the pathogenesis is ex-tremely complex.Estimated glomerular filtration rate(eGFR),urinary microalbumin,urea nitrogen,creatinine and other indicators are usually used in clinical diagnosis,but the changes in these indicators are relatively delayed compared to renal damage,and there are many factors that affect the results,so specificity and sensitivity are not ideal.Therefore,exploring biomarkers related to early diag-nosis of diabetic kidney disease has far-reaching significance for its prevention and treatment.In recent years,podocytes and their marker proteins have become the focus of research,and are expected to become markers for the early diagnosis of DKD.
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