Research progress on the role of PSD-95 gene DNA methylation modification in sleep deprivation related diseases
Sleep deprivation(SD)is a widespread problem worldwide and is associated with various diseases.It has been found that the epigenetic mechanism is closely related to the occurrence and development of SD and related diseases,among which DNA methylation is the most common epigenetic modification that can affect gene expression.Postsynaptic density protein-95(PSD-95)is considered an important regulatory factor in the process of excitatory signaling.After SD,the expression of PSD-95 decreases,exhibi-ting symptoms of mental illness such as emotional changes and cognitive impairment.In chronic stress mice,an increase in DNA meth-ylation levels in the promoter region of serotonin 1A receptor is observed,which is associated with a decrease in PSD-95 expression lev-els in the prefrontal cortex of patients with depression.However,the DNA methylation level of the PSD-95 gene is not associated with the phenotype of depression.In patients with schizophrenia,the length of SD can exacerbate the severity of the disease,and DNA methylation of the PSD-95 gene is associated with schizophrenia.In addition,the risk of colorectal cancer is associated with SD or cir-cadian rhythm disorders,and DNA methylation of the PSD-95 gene may also become a target for the treatment of colorectal tumors.Further researches are needed to explore the role and regulatory mechanism of DNA methylation of the PSD-95 gene in SD-related dis-eases.
sleep deprivation(SD)postsynaptic density protein-95(PSD-95)DNA methylationepigenetic
万方数据
维普
