Effect of type 2 diabetes mellitus complicated with β-thalassemia on renal function
Objective To observe the changes of renal function in patients with type 2 diabetes mellitus(T2DM)com-plicated with β-thalassemia,so as to explore the effect of T2DM complicated with β-thalassemia on renal function.Methods A retrospective analysis of 197 patients diagnosed with T2DM in the department of endocrinology of Affiliated Hospital of Youjiang Medical University for Nationalities from January 2018 to July 2022 was conducted.According to whether the pa-tients were complicated with β-thalassemia,they were divided into complicated β-thalassemia group(T2DM + β-thalassemia group,111 cases)and simple T2DM group(T2DM group,86 cases).The general data and clinical data of the patients were collected,and differences between the two groups were compared.In addition,logistic regression analysis was used to explore the risk factors of renal dysfunction in T2DM combined with β-thalassemia.Results There was no statistically sig-nificant difference in age,sex,nation,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),very low density lipoprotein cholesterol(VLDL-C)between the two groups(P>0.05).And the differences of uri-nary creatinine(Cr),creatinine clearance rate(CCR),glomerular filtration rate(GFR),cystatin C(Cysc),red blood cell(RBC),hemoglobin(HGB),hematocrit(HCT),mean hemoglobin content(MCH),mean hemoglobin concentration(MCHC),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipopro-tein cholesterol(LDL-C)were statistically significant(P<0.05 or 0.001).And the above-mentioned differences were ana-lyzed by logistic regression,which results showed that HGB,RBC,HCT,MCH,Cr,CCR and Cysc were risk factors for GFR decline(P<0.05 or 0.001).Conclusion Patients with T2DM complicated with β-thalassemia are more likely to have renal dysfunction.HGB,RBC,HCT,MCH,Cr,CCR and Cysc are risk factors for GFR decline in them.
万方数据
维普
