Effect of 10%hypertonic saline combined with furosemide on high intracranial pressure after cerebral infarction and its impact on blood sodium
Objective To investigate the efficacy of 10%hypertonic saline(HTS)combined with furosemide in the treatment of intracranial hypertension after cerebral infarction and its influence on blood sodium.Methods A total of 60 pa-tients with acute massive cerebral infarction complicated with high cranial pressure who were treated in the inpatient depart-ment of the Encephalopathy Department of Guilin Municipal Hospital of Traditional Chinese Medicine from 2020 to 2023 were selected.They were randomly divided into observation group 1,observation group 2 and control group by digital table,with 20 cases in each group.The observation group 1(group A)were treated with 10%HTS 60 mL by intravenous drip combined with furosemide 40 mg by micro-pump(specific frequency was adjusted according to intracranial pressure),the observation group 2(group B)were treated with 10%HTS 60 mL by intravenous injection,and the control group(group C)were trea-ted with 125 mL mannitol(MT)by intravenous drip.Intracranial pressure(ICP)and mean arterial pressure(MAP)of the three groups were monitored continuously,and corresponding cerebral perfusion pressure(CPP)was calculated according to ICP and MAP.The duration of effective reduction of intracranial pressure,the maximum reduction and duration of intracrani-al pressure in enrolled patients were recorded,and the blood sodium value before medication,2 hours and 6 hours after med-ication were recorded.Results ICP,MAP,CPP and blood sodium of the three groups in different time periods were statis-tically significantly different(P<0.05).After 2 h and 6 h of medication,the ICP of the group A was lower than that of the group B and the group C(P<0.05),MAP and CPP were higher than those of the group B and the group C(P<0.05),and serum sodium value in the group A was lower than that in the group B(P<0.05).Conclusion 10%HTS can effectively reduce ICP in patients with acute large area cerebral infarction,and furosemide can reduce the influence of hypertonic saline on blood sodium.
万方数据
维普
