Clinical analysis of 810 nm semiconductor laser and fruit acid in the treatment of keratosis pilaris
Objective To investigate the curative effect of 810 nm semiconductor laser and fruit acid skin rejuvenation in the treatment of keratosis pilaris.Methods 43 patients with arm peridermal keratosis who were treated in outpatients in the department of dermatology from September 2020 to March 2022 were randomly divided into self control group(18 cases)and combined treatment group(25 cases).In the control group,left upper arms were treated with 810 nm semiconductor laser,and right upper arms were treated with 70%fruit acid,while in the combined treatment group,both upper arms were treated with 810 nm semiconductor laser and 70%fruit acid alternately.Treatment interval was 4 weeks for a total of 3 times.And then,clinical efficacy after 1 month and 6 months was compared and analyzed.Results After treatment,patients were revisited at 1 month and 6 months,respectively,and there was no statistically significant difference in the overall clinical efficacy among the three groups at 1 month after treatment(P>0.05).After 6 months of treatment,there was statistically significant difference in the overall clinical efficacy among the three groups(P=0.003),and the combined treatment group had a higher overall effica-cy than both fruit acid treatment and laser treatment(P<0.05 or 0.01).After 1 month of treatment,the water content in the stratum corneum of all subjects significantly increased,but after 6 months of retesting,the values decreased slightly,and there was statistically significant difference between the groups(P<0.01).After 6 months of treatment,the combined treatment group had a higher water content in the stratum corneum(P<0.01).After 1 month of treatment,the transcutaneous water loss of all subjects was significantly reduced.After 6 months,the values of fruit acid treatment and laser treatment were tested a-gain,and the values showed a rebound,and the differences between the groups were statistically significant(P<0.01).After 6 months of treatment,the combined treatment group had less transcutaneous water loss(P<0.01).No significant adverse re-actions were found in all patients during treatment.Conclusion The curative effect of 810 nm laser combined with fruit acid in the treatment of peridermal keratosis is better than that of laser or fruit acid alone.It has fewer adverse reactions,convenient operation and good short-term effect,and thus is worthy of clinical application.
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