Clinical study on the effect of general anesthesia on brain development of infants
Objective To investigate the effect of general anesthesia on postoperative brain development of infants.Meth-ods A retrospective analysis was performed on 429 children aged 0-3 years(study group)who underwent surgical treatment under general anesthesia in the First Affiliated Hospital of Guangxi Medical University from 2012 to 2015 when they were 3-6 years old.According to the characteristics of urban areas,age,gender and ethnicity of children in the study group,a 1∶1 matching design was adopted.A total of 429 children aged 3-6 years who did not receive general anesthesia during the period of 0-3 years old were selected as controls.The anesthesia records and basic information of the children in the study group were reviewed and recorded.Children in the study group were divided into three groups according to the duration of anesthesia:＜1 h group(A1 group),1-2 h group(A2 group),and＞2 h group(A3 group),two groups according to the number of sur-gical anesthesia:1 time group(B1 group),2 times group(B2 group),and three groups according to recovery time:＜30 min group(C1 group),30-60 min group(C2 group),and＞60 min group(C3 group).The fourth edition of the Wechsler Pre-school and Primary Scale of Intelligence(WPPSI-Ⅳ)was used to comprehensively evaluate the overall cognitive ability and in-tellectual activity level of the above children,the total score of the Achenbach Children's Behavior Scale(CBCL)was used to evaluate children's behaviors,emotions,and social abilities,while the Gesell Development Scale(Gesell)was used to evaluate children's central nervous system functions and developmental levels.Results Among the children aged 2 years and 6 months to 4 years old who were suitable for the WPPSI-Ⅳ:compared with the control group,the working memory index score of the children in the study group decreased;among the children aged 4 to 6 years and 11 months who were suitable for the WPPSI-Ⅳ:compared with the control group,the children in the study group showed a decrease in speech comprehension,fluid reason-ing,processing speed,working memory index scores,and developmental quotient of the Gesell scale(P＜0.05).Compared with the group A1 and the group A2,the scores of total intelligence quotient and working memory index in the group A3 de-creased(P＜0.05);compared with the group B1,the scores of total intelligence quotient,working memory index and develop-mental quotient in the group B2 decreased(P＜0.05).There was no statistically significant difference in the recovery time be-tween the groups(P＞0.05).Conclusion Infants receiving general anesthesia during brain development may have an impact on their nervous system developments.Infants who receive general anesthesia twice or for a duration greater than 2 hours are more susceptible to short-term memory,storage,processing,and output of information during intellectual development.
general anesthesiainfantsbrain developmentclinical research
万方数据
维普
