Expression and clinical significance of CARDS TX,HMGB1 and TLR2 in bronchoalveolar lavage fluid in children with mycoplasma pneumoniae pneumonia
Objective To investigate the expressions of community-acquired respiratory distress syndrome toxin(CARDS TX),high mobility group box-1 protein(HMGB1)and Toll-like receptors 2(TLR2)in bronchoalveolar lavage fluid in chil-dren with mycoplasma pneumoniae pneumonia(MPP),and to explore the clinical significance of CARDS TX,HMGB1 and TLR2 in the pathogenesis of MPP.Methods Retrospective analysis was carried out on the clinical data of 55 MPP children and 20 children in control group.And the expressions of CARDS TX,HMGB1,TLR2,TLR4,receptor of advanced glyca-tion endproducts(RAGE)and myeloid differentiation primary response 88(MyD88)in bronchoalveolar lavage fluid(BALF)of the two groups.In addition,the expressions of HMGB1 and TLR2 after stimulation with different concentrations of CARDS TX in vitro were detected and compared.Results Compared with the control group,LYM absolute value count,PA,CD3+,CD3+CD4+,CD3+CD8+,CD3-CD19+,NK cell,and CD19+CD23+were significantly decreased,while CRP,LDH,D-dimer,IgA,IgG,IgM,CARDS TX,HMGB1,TLR2 and MyD88 were significantly increased,and difference was statistically significant(P<0.05 or 0.001).The expression of HMGB1 and TLR2 increased after CARDS TX stimulation,there was a positive correlation between them,and difference was statistically significant(P<0.001).Conclusion CARDS TX may be involved in the pathogenesis of mycoplasma pneumoniae(MP)through HMGB1-TLR2-MyD88 pathway.
万方数据
维普
