目的 分析真实世界中糖尿病与泌尿系结石的关系,为泌尿系结石的预防及治疗提供依据.方法 收集2015 年 1 月 1 日至2019 年12 月31 日诊断有糖尿病、泌尿系结石及同期在体检中心常规体检人员的临床资料,分别设为糖尿病组、结石组、对照组(非糖尿病健康对照组和非结石健康对照组),记录各组的性别、年龄、是否有糖尿病、是否有血脂异常、是否有肾功能异常、是否有泌尿系结石等指标,倾向性评分匹配法匹配基线水平后,比较糖尿病组与非糖尿病健康对照组的结石发生率,结石组与非结石健康对照组的糖尿病发生率,探究临床真实世界中糖尿病与泌尿系结石的关系.结果 经过校正组间性别、年龄、血脂水平、肾功能水平的差异后,糖尿病组患者的泌尿系结石发生率高于非糖尿病健康对照组(11.63% VS 5.42%),差异有统计学意义(χ2=163.561,P<0.001);结石组患者的糖尿病发生率高于非结石健康对照组(15.70% VS 11.71%),差异有统计学意义(χ2=40.171,P<0.001).结论 临床真实世界中糖尿病与泌尿系结石发病存在密切的关系,对糖尿病患者的早期有效干预可能有利于泌尿系结石的预防.
A study on relationship between diabetes mellitus and urinary stones in clinical real world
Objective To analyze relationship between diabetes mellitus and urinary stones in clinical real world,so as to provide evidence for the prevention and treatment of urinary stones.Methods Clinical data of patients diagnosed with di-abetes or urinary stones and people who underwent regular check-ups at medical examination center between January 1,2015 and December 31,2019 were collected and divided into diabetes group,stone group,and control groups(non-diabetic healthy control group,and non-stone healthy control group).Indexes including gender,age,presence of diabetes,blood lip-id abnormalities,renal dysfunction,and urinary stones of each group were recorded.After matching baseline levels by pro-pensity score matching,the incidence of stones between the diabetes group and the non-diabetic healthy control group,and the incidence of diabetes mellitus between the stone group and the non-stone healthy control group were compared to explore the relationship between diabetes and urinary stones in clinical real world.Results After adjusting for differences in gen-der,age,blood lipid levels,and renal function levels between groups,the incidence of urinary stones was significantly high-er in the diabetes group than in the non-diabetic healthy control group(11.63% vs5.42%),and difference was statistically significant(χ2=163.561,P<0.001),while the incidence of diabetes was significantly higher in the stone group than in the non-stone healthy control group(15.70% vs 11.71%),and difference was statistically significant(χ2=40.171,P<0.001).Conclusion There is a close relationship between diabetes mellitus and urinary stones in the clinical real world,and early effective intervention for diabetic patients may be beneficial for the prevention of urinary stones.
diabetes mellitusurinary stonespropensity score matchingreal-world study
万方数据
维普
