Comparison of thrombosis prevention strategies after iliac vein stent surgery
Objective To compare the efficacy and bleeding risk of different drug regimens for preventing stent thrombo-sis after iliac vein stent placement,so as to explore drug prevention strategies for thrombosis after iliac vein stent surgery.Methods A retrospective analysis was conducted on 97 patients with iliac vein compression syndrome treated with stents at the First People's Hospital of Shangqiu from January 2019 to June 2021.They were divided into three groups according to different treatment plans:anticoagulant group were treated with rivaroxaban 20 mg(Group 1,31 cases),anticoagulant+anti-platelet group were treated with rivaroxaban 10 mg+aspirin(Group 2,37 cases),and antiplatelet group were treated with aspirin alone(Group 3,29 cases).Postoperative medication course was 12 months,and the results of color ultrasound or venous angiography results of the three groups were followed up at different times(1 month,3 months,6 months,12 months,24 months)to estimate the thrombosis situation in the iliac vein stent.Meanwhile,the incidence of thrombosis and bleeding events was compared among the three groups.Results All 97 patients were followed up,and at 24 months,the in-cidence of stent thrombosis in the antiplatelet group(Group 3),the anticoagulant group(Group 1),and the anticoagulant+antiplatelet group(Group2)was27.59%,9.68% and2.70%,respectively,and the difference of the incidence of throm-bosis among the three groups was statistically significant(P<0.05).The total bleeding rate of the antiplatelet group(Group 3),the anticoagulant group(Group 1),and the anticoagulant+antiplatelet group(Group 2)was 10.34%,29.03% and 32.43%,respectively,and difference was not statistically significant(P>0.05).The total bleeding rate of Group 1+Group 2 was 30.88%,which was higher than that of the Group 3(10.34%),and difference was statistically significant(P<0.05).The incidence rates of mild bleeding in the Group 1,the Group 2,and the Group 3 were 25.81%,27.03%,and 6.90%,respectively(P>0.05),while the incidence rates of severe bleeding in the Group 1,the Group 2,and the Group 3 were 3.23%,5.41%,and 3.45%,respectively(P>0.05).Conclusion Rivaroxaban 10 mg combined with aspirin has a better therapeutic effect in preventing thrombosis in iliac vein stents.It can significantly reduce the incidence of thrombosis in stents,improve the patency rate of iliac vein stents without significantly increasing the risk of bleeding,which has certain ad-vantages in preventing thrombosis after iliac vein stent placement and is worthy of clinical application.
万方数据
维普
