老年营养风险指数与进展期非小细胞肺癌患者预后的相关性分析
Analysis on association between geriatric nutritional risk index and prognosis of advanced non-small cell lung cancer patients
高珊 1吕艳茹 2谢嫣嫣 1黄琴 3陈晓丹 1陆水 1竺建芳 1蒿艳蓉1
作者信息
- 1. 广西医学科学院·广西壮族自治区人民医院临床肿瘤中心肿瘤内科一区,广西南宁 530021
- 2. 广西医学科学院·广西壮族自治区人民医院科研合作部,广西南宁 530021
- 3. 广西玉林市红十字会医院肿瘤化疗科,广西玉林 537000
- 折叠
摘要
目的 探讨老年营养风险指数(GNRI)与进展期非小细胞肺癌(NSCLC)患者预后的相关性.方法 回顾性分析 2017 年 1 月至 2021 年 12 月在广西壮族自治区人民医院肿瘤内科确诊并接受一线标准化疗的驱动基因阴性的老年进展期NSCLC患者共 117 例.收集患者的基线资料、实验室检验及影像学结果,并通过多种方式随访患者的生存状态.结果 与高GNRI组(GNRI＞98,n=35)相比,低GNRI组(GNRI≤98,n=82)患者更容易出现胸膜转移及白蛋白下降,两组间差异有统计学意义(P＜0.05).根据Kaplan-Meier曲线,低GNRI组具有更差的无进展生存期(9个月vs 19 个月,P＜0.001)和总生存期(16 个月vs 41 个月,P＜0.001).单因素及多因素分析显示,低GNRI是影响患者总生存期的独立危险因素(P＜0.05).结论 GNRI是老年进展期NSCLC患者疗效及生存简单有效的潜在预测指标,低GNRI可能与预后更差相关.
Abstract
Objective To investigate the relevance of geriatric nutritional risk index(GNRI)on the prognosis of patients with advanced non-small cell lung cancer(NSCLC).Methods A total of 117 elderly advanced NSCLC patients with nega-tive driver gene who were diagnosed in the Department of Medical Oncology of the People's Hospital of Guangxi Zhuang Au-tonomous Region from January 2017 to December 2021 were retrospectively analyzed.The baseline data of the patients,labo-ratory test results,and imaging findings were collected,and the survival status of the patients were followed up through vari-ous methods.Results Compared with the high GNRI group(GNRI＞98,n=35),patients in the low GNRI group(GNRI≤98,n=82)were more likely to experience pleural metastasis and decreased albumin,and difference between the two groups was statistically significant(P＜0.05).According to the Kaplan Meier curve,the low GNRI group had worse progression free survival(9 months vs 19 months,P＜0.001)and overall survival(16 months vs 41 months,P＜0.001).Univariate and multivariate analyses showed that low GNRI was an independent risk factor for overall survival(P＜0.05).Conclusion GNRI is a simple and effective potential predictor of outcome and survival in elderly patients with progressive NSCLC,and low GNRI may be associated with worse prognosis.
关键词
进展期肺癌/老年营养风险指数/预后/生存分析Key words
advanced lung cancer/geriatric nutritional risk index(GNRI)/prognosis/survival analysis引用本文复制引用
基金项目
广西重点研发计划项目(桂科-AB21196012)
广西卫健委自筹经费科研课题(Z20210544)
出版年
2024
国家科技期刊平台
NSTL
万方数据