Effects of butylphthalide injection on neurotransmitters,inflammatory factors and electroencephalogram in patients with large area cerebral infarction
Objective To investigate the effects of butylphthalein injection on neurotransmitters,inflammatory factors and electroencephalogram in patients with large area cerebral infarction.Methods A total of 120 patients with large area cerebral infarction admitted to hospital from September 2019 to September 2020 were included and divided into control group and obser-vation group according to random number table,with 60 cases in each group.The control group were given routine treatment,and the observation group were treated with butylphthalide injection on the basis of routine treatment.All patients were continu-ously treated for two weeks.And then,total clinical efficacy rate,neurotransmitters(neuron-specific enolase[NSE],neu-ropeptide Y[NPY],brain-derived neurotrophic factor[BDNF]),inflammatory factors(protein phospholipase A2[LP-PLA2],interleukin-6[IL-6]and hypersensitive C-reactive protein[hs-CRP])and slow-wave ratio of electroencephalogram were observed.Results After treatment,the total clinical efficacy rate(81.67%vs 55.00%)in the observation group was significantly higher than that in the control group(P＜0.01).The serum levels of NSE([10.22±1.30]mg/L vs[14.35±2.60]mg/L),NPY([116.25±6.38]ng/Lvs[150.17±8.22]ng/L)intheobservationgroupweresignificantlylowerthan those in the control group(P＜0.001),and the serum levels of BDNF([7.52±1.48]ng/mL vs[5.31±1.06]ng/mL)in the observation group were significantly higher than those in the control group(P＜0.001).The serum levels of Lp-PLA2([25.47±4.13]μg/L vs[41.83±5.36]μg/L,IL-6[88.65±4.28]pg/L vs[101.39±6.10]pg/L,and hs-CRP[4.10±0.62]ng/L vs[7.78±1.55]ng/L)in the observation group were significantly lower than those in the control group(P＜0.001).The slow-wave ratio of electroencephalogram([2.36±0.59]vs[4.27±1.16])in the observation group was significantly lower than that in the control group(P＜0.001).Conclusion Butylphthalein injection can improve the levels of neurotransmitter,inhibit in-flammatory response and improve the clinical efficacy of patients with large area cerebral infarction.
large area cerebral infarctionbutylphthalide injectionneurotransmittersinflammatory factorselectroen-cephalogram
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