Evaluation of the effect of sodium valproate combined with murine nerve growth factor in the treatment of refractory epilepsy
Objective To study the effect of sodium valproate combined with murine nerve growth factor in the treatment of refractory epilepsy.Methods 60 cases of children with refractory epilepsy admitted to hospital from January 2021 to June 2022 were selected as research subjects.And they were divided into control group and combination group according to ran-dom number table,with 30 cases in each group.The control group were treated with sodium valproate oral solution,and the combination group were treated with sodium valproate oral solution combined with murine nerve growth factor.And then,clinical efficacy,seizure frequency before treatment,after 8 weeks of treatment,and after 16 weeks of treatment as well as cognitive function(orientation,calculation,language ability,memory),serum glial fibrillary acidic protein(GFAP),neu-ron-specific enolase(NSE),α-synuclein(α-syn),heat shock protein 70(HSP70)levels,and the incidence of adverse effects were compared between the two groups.Results The total clinical effective rate of the combination group was 93.33%,and the total clinical effective rate of the control group was 70.00%,and difference was statistically significant(P＜0.05).Compared with that before treatment,the seizure frequency was lower in both groups after 8 and 16 weeks of treatment,and it was lower in the combination group than in the control group(P＜0.001).Compared with those before treatment,orientation,numeracy,language ability and memory scores were higher in the 2 groups after 8 and 16 weeks of treatment,and those in the combination group were higher than those in the control group(P＜0.001).Compared with those beforetreatment,serumGFAP,NSE,α-synandHSP70levelswerelowerinthe2groupsafter8and16weeksoftreatment,and those of the combination group were lower than those of the control group(P＜0.001).The total incidence of adverse re-actions in the combination group was 13.33%,while the total incidence of adverse reactions in the control group was 6.67%,and difference between the two groups was not statistically significant(P＞0.05).Conclusion Sodium valproate o-ral solution combined with murine nerve growth factor for the treatment of children with refractory epilepsy has higher clinical efficacy,which can significantly alleviate seizures and neurological impairment,improve cognitive function,and has certain degree of safety.
国家科技期刊平台
NSTL
万方数据
