摘要
目的 探讨普拉克索片联合多巴丝肼片治疗帕金森病(PD)的有效性及对活化T细胞趋化因子(RAN-TES)、α-突触核蛋白(α-syn)的影响.方法 以 2019 年 4 月至 2021 年 9 月洛阳市东方人民医院收治的 84 例PD患者为研究对象,采用随机数字表将患者分为对照组和联合组,各 42 例.对照组给予多巴丝肼片治疗,联合组在此基础上给予普拉克索片治疗.比较两组临床疗效及治疗前、治疗 1 个月、治疗 3 个月后帕金森病综合评分量表(UP-DRS)、蒙特利尔认知评估量表(MoCA)、日常生活能力量表(ADL)、P300(潜伏期、波幅)、疾病相关指标[白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、RANTES、α-syn]、不良反应.结果 联合组临床总有效率为 95.24%,高于对照组的 78.58%(P＜0.05);与对照组相比,治疗 1 个月、3 个月后联合组UPDRS评分明显降低,MoCA、ADL评分明显升高(P＜0.05);与治疗前相比,治疗 1 个月、3 个月后两组P300 潜伏期明显缩短,波幅明显升高,其中联合组改变更为显著(P＜0.05);与治疗前相比,治疗 1 个月、3 个月后两组血清IL-6、IL-1β、RANTES、α-syn水平均呈持续下降趋势,其中联合组下降更为显著(P＜0.05);联合组不良反应发生率为11.90%,与对照组的7.14%相比,差异无统计学意义(P＞0.05).结论 多巴丝肼片联合普拉克索片治疗PD疗效确切,能有效改善患者神经功能和认知功能,减轻炎症反应,提高生活质量,安全可靠,其机制可能与调控RANTES、α-syn表达有关.
Abstract
Objective To explore the effectiveness of pramipexole tablets combined with dopazazine tablets in the treat-ment of Parkinson's disease(PD)and its effects on activated T cell chemokines(RANTES)and α-synuclein(α-syn).Methods A total of 84 patients with PD admitted to Luoyang Oriental People's Hospital from April 2019 to September 2021 were selected as research objects.They were divided into control group and combination group by random number table,with 42 cases in each group.The control group were given dopamazide tablets,and the combination group were given pramexol tablets on this basis.And then,clinical efficacy as well as the Comprehensive Parkinson's Disease Scale(UPDRS),Mont-real Cognitive Assessment(MoCA)Scale,Activity of Daily Living(ADL)Scale,P300(latency,amplitude),disease-re-lated indicators(interleukin-6[IL-6],interleukin-1β[IL-1β],RANTES,α-syn)before treatment,at 1 month and 3 months after treatment,and adverse reactions of the two groups were compared.Results The total effective rate of the com-bination group was 95.24%,which was higher than that of the control group(78.58%)(P＜0.05).Compared with the control group,after 1 month and 3 months of treatment,the UPDRS scores of the combination group were significantly de-creased,while the MoCA and ADL scores were significantly increased(P＜0.05).Compared with those before treatment,the P300 latency of the two groups was significantly shortened,and the amplitude of the wave was significantly increased after 1 month and 3 months of treatment,and change in the combination group was even more significant(P＜0.05).Compared with those before treatment,serum levels of IL-6,IL-1β,RANTES and α-syn in the two groups were decreased continuously after 1 month and 3 months of treatment,especially in the combination group(P＜0.05).The incidence of adverse reactions in the combination group was 11.90%,compared with 7.14%in the control group,the difference was not statistically signifi-cant(P＞0.05).Conclusion Dopamazid tablets combined with pramexol tablets are effective in the treatment of PD,which can effectively improve the neurological function and cognitive function of patients,reduce inflammation,relieve the disease,and improve the quality of life.
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