Analysis of clinical characteristics of two different subtypes of influenza A in children
Objective To compare the clinical characteristics of different subtypes of influenza A in hospitalized chil-dren,so as to provide reference for clinical diagnosis,treatment,and prevention strategies.Methods Statistical analysis was performed on the number of cases diagnosed with influenza A that met the diagnostic criteria in Quanzhou Children's Hos-pital from January 2022 to July 2023.Clinical data of hospitalized children were retrospectively analyzed to compare the age distribution,clinical manifestations,laboratory tests,and clinical outcomes of different subtypes.Results Among the 317 hospitalized children who met the diagnostic criteria for influenza A,209 cases(accounting for 65.9%)were identified as subtype H1N1 of influenza A,and 108 cases(accounting for 34.1%)were identified as subtype H3N2 of influenza A.There was a difference in the distribution of hospitalized children across different age groups,with the highest number of chil-dren aged 2 to 6 years old,accounting for 53.3%of the total hospitalized population.In terms of clinical manifestations,cough,wheezing,nasal congestion/runny nose,and convulsions were more commonly seen in the influenza A H3N2 group,while diarrhea and vomiting were more common in the influenza A H1N1 group,and differences were all statistically signifi-cant(P<0.001).There was no statistically significant difference in laboratory tests between the two subtypes of influenza(P>0.05).The influenza A H3N2 group had higher rate of admission to the intensive care unit,longer hospital stay,and higher rates of pneumonia/atelectasis,influenza-associated encephalopathy,and electrolyte imbalances,and difference was statistically significant(P<0.05 or 0.001).Conclusion There are significant differences in the clinical characteristics of different subtypes in children,and the specific characteristics of these subtypes should be taken into full consideration when implementing preventive and treatment measures.
influenzaH1N1 virus infection of influenza AH3N2 virus infection of influenza Aclinical feature
万方数据
维普
