Changes in serum immunoglobulin levels in children before and after treatment with different antiepileptic drugs
Objective To observe the changes in serum immunoglobulin levels in children before and after treatment with different antiepileptic drugs.Methods 57 children with idiopathic epilepsy admitted to the pediatrics department of Jiang-men Central Hospital from June 2020 to March 2022 were selected.According to different types of seizures in patients,treat-ment group were divided into ① valproate sodium treatment group with 30 cases(generalized seizures);② oxcarbazepine treatment group with 12 cases(focal seizures);③perampanel treatment group with 15 cases(focal seizures).At the same time,69 children who underwent health check ups in the outpatient department during the same period were selected as con-trol group.The serum immunoglobulin IgG,IgM and IgA levels in each group were measured,and the serum immunoglobulin IgG,IgM and IgA levels in each treatment group were tested and compared with those of the control group to analyze the changes of serum immunoglobulin levels before and after medication in different treatment groups.Results The sodium val-proate group(generalized seizures)had impaired humoral immune functions before treatment,compared with the control group,the levels of serum immunoglobulin IgA and IgG decreased significantly.After treatment,the levels of serum immuno-globulin IgG increased significantly and IgM decreased significantly compared to those before medication,and difference was statistically significant(P<0.001);but there was no significant change in serum immunoglobulin IgA levels(P>0.05).Before treatment,the serum levels of immunoglobulins IgG,IgM,and IgA in the oxcarbazepine group and perampanel group(focal seizures)showed no significant changes compared to those in the control group.After treatment,the serum levels of immunoglobulins IgG,IgM,and IgA showed no significant changes compared to those before treatment,and difference was not statistically significant(P>0.05).Conclusion Before treatment,humoral immune functions are impaired in children with epilepsy,especially in children with generalized seizures,but it is not obvious in the children with focal seizures.Val-proate sodium has obvious immunomodulatory effect,but oxcarbamazine and piranpanet have no immunomodulatory effects.
万方数据
维普
