Relationship between serum levels of HIF-1α,TK1,and γ-GT and the prognosis of TACE treatment in patients with primary liver cancer
Objective To explore the predictive value of serum hypoxia inducible factor-1α(HIF-1α),thymidine kinase 1(TK1),and γ-glutamyltransferase(γ-GT)for the prognosis of patients with primary liver cancer undergoing transcatheter arterial chemoembolization(TACE).Methods 172 patients with primary liver cancer who received TACE treatment from October 2019 to October 2022 were selected as cancer group,and 156 healthy individuals who underwent physical examina-tions during the same period were selected as control group.Enzyme linked immunosorbent assay(ELISA)was used to de-tect serum HIF-1α and TK1 levels,and a fully automatic analyzer was used to detect serum γ-GT level.Relationship be-tween the serum levels of HIF-1α,TK1,and γ-GT and the clinical and pathological characteristics of patients was analyzed.Univariate and multivariate analysis were carried out on the influencing factors of poor prognosis after TACE treatment in pa-tients with primary liver cancer.In addition,receiver operating characteristic(ROC)curve was used to analyze the detection of serum HIF-1α,TK1,and γ-GT for predicting poor prognosis in patients with primary liver cancer after TACE treatment.Results The serum levels of HIF-1α,TK1,and γ-GT in the cancer group were higher than those in the control group(P<0.001),and the serum levels of HIF-1α,TK1,and γ-GT in cancer patients were correlated with vascular invasion,tumor diameter,and lesion number(P<0.05 or 0.001).Serum HIF-1α,TK1,and γ-GT were influencing factors for the poor prognosis of the patients(P<0.05 or 0.001).The ROC area under the curve(AUC)predicted by the combination of serum HIF-1α,TK1,and γ-GT for poor prognosis was significantly larger than that predicted by HIF-1α alone(Z=2.712,P=0.007),TK1 alone(Z=3.642,P<0.001),and γ-GT alone(Z=3.347,P<0.001).Conclusion After TACE treat-ment,the serum levels of HIF-1α,TK1,and γ-GT in patients with primary liver cancer increase,and combined detection of these levels has good predictive value for poor prognosis in patients.
万方数据
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