Correlation and diagnostic value of serum sEng,PLGF,LDH levels in hypertensive patients during pregnancy
Objective To investigate correlation between serum soluble endoglin(sEng),placenta growth factor(PL-GF)and lactate dehydrogenase(LDH)levels and hypertensive disorders complicating pregnancy(HDCP)and its diagnostic value.Methods 100 HDCP patients admitted to hospital from January 2021 to May 2022 were selected as observation group,and 100 healthy pregnant women during the same period were selected as control group.The levels of serum sEng,PLGF,and LDH in patients with different severity of the disease at the time of admission were compared,and correlation be-tween the levels of these indicators at admission and the severity of the disease was analyzed.The influencing factors of HD-CP were analyzed by logistic regression,and the diagnostic value of combined detection of each index at admission was ana-lyzed by ROC.Results At admission,serum sEng and LDH levels were compared:observation group>control group,HD-CP<preeclampsia<severe preeclampsia;PLGF levels were compared:observation group<control group,HDCP>pre-eclampsia>severe preeclampsia(P<0.05);serum sEng and LDH levels were positively correlated with the severity of HD-CP patients at admission,while PLGF levels were negatively correlated with the severity of HDCP patients(P<0.001).At admission,serum sEng and LDH levels were risk factors for HDCP,and PLGF levels were protective factors.The AUC for combined diagnosis of HDCP was 0.815.Conclusion The levels of serum sEng,PLGF,and LDH are closely related to the severity of HDCP,and combined detection has certain diagnostic value for HDCP,which can provide a reliable reference for early clinical diagnosis and assessment of disease severity.
万方数据
维普
