Progress on pathogenesis,diagnosis and treatment of lupus nephritis
Lupus nephritis ( LN) is the most serious target organ damage in systemic lupus erythematosus ( SLE),and it is also an important cause of morbidity and mortality in SLE patients.The pathogenesis of LN is mainly related to the excessive activation of the immune system and the clearance of immune complexes caused by multiple factors.As the gold standard for the diagnosis of LN,renal biopsy is invasive and expensive,and some medical institutions have not yet conducted it.The discovery of new biomarkers pro-vides a new method for early diagnosis,efficacy monitoring,and prognosis evaluation of LN.The continuous progress of medicine not only promotes the development of biologics,but also provides new perspectives for traditional therapeutic drugs,realizing the new use of old drugs.At present,the pathogenesis of LN is constantly deepening,and its diagnosis and treatment are also developing towards more precise,non-invasive,and personalized directions.With the continuous development of targeted drugs and the launch of various biolog-ical preparations,new options for the treatment of LN have been provided,and the survival rate of LN patients has significantly im-proved than before.However,further clinical studies are still needed on the efficacy and safety of the long-term use of new drugs.
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