Association between residual inflammatory risk and in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention
Association between residual inflammatory risk and in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention
Objective To explore association between residual inflammatory risk (RIR) and in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods A prospective selec-tion of 383 ACS patients who received PCI at cardiology department from January 1,2022 to May 31,2023,with low-density lipoprotein cholesterol (LDL-C) levels below 1.8 mmol/L,was conducted.Patients were divided into ISR group (n=43) and non ISR group ( n=340) based on whether ISR occurred during 1-year follow-up after surgery.The correlation between high-sensitivity C-reactive protein (hs-CRP) levels and ISR was analyzed by KM analysis and multivariate Cox proportional hazard regression model.Results The hs-CRP of the ISR group was (35.1±51.1) mg/L,while that of the non ISR group was (3.1±3.1) mg/L,and difference between the two groups was statistically significant (t=11.490,P<0.001),and the hs-CRP levels in the ISR group was higher than those in the non ISR group.Kaplan-Meier analysis results showed that compared to the low hs-CRP group,the risk of ISR within one year was significantly higher in the high hs-CRP group ( P<0.001).In Cox proportional hazard regression model,after adjusting for traditional risk factors,each increase of hs-CRP by 1 mg/L in-creased the risk of ISR by 3％ ( HR=1.03,95％ CI:1.02-1.04,P<0.001),and compared with the low hs-CRP group,the risk in the high hs-CRP group increased by 333％ (HR=4.33,95％ CI:1.97-9.52,P<0.001).Conclusion In ACS pa-tients whose LDL-C levels meet the standards after PCI treatment,hs-CRP levels are associated with the occurrence of ISR.
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