摘要
归纳微小RNA142(miR-142)的生物学功能及其在临床中的应用,指出miR-142通过PI3K/AKT/mTOR、MAPK/ERK及NF-κB等信号通路在不同疾病中的调控,因其活性类型不同而异,进而对特定蛋白质和分子的靶向作用,对细胞增殖、自噬、凋亡、迁移及侵袭的生物学功能及其主要研究进展进行了探讨.miR-142的表达水平受到基因启动子区CpG岛异常甲基化的影响,在多种恶性肿瘤中能够影响化疗药物的敏感性.在此基础上,对miR-142作为分子医学潜在治疗靶点的价值进行了深入分析,揭示了 miR-142作为潜在治疗靶点的可能性,并展望了其作为非侵入性生物标志物在疾病预后评估与早期诊断中的应用前景.
Abstract
This article summarizes the biological functions of miR-142 and its clinical application,and points out that miR-142 regulates the biological functions of cell proliferation,autophagy,apoptosis,migration and invasion through PI3K/AKT/mTOR,MAPK/ERK and NF-κB signaling pathways.The signaling pathways regulated in different diseases vary according to their activity types,targeting specific proteins and molecules,thereby regulating cell proliferation,autophagy,apoptosis,migration and invasion.The expression level of miR-142 is affected by the abnormal methylation of CpG islands in its promoter region.MiR-142 can affect the sensitivity of chemotherapeutic drugs in a variety of malignant tumors.On this basis,the value of miR-142 as a potential therapeutic target for molecular medicine,is discussed in depth,and the possibility of miR-142 as a potential therapeutic target is revealed.The application prospect of miR-142 as a non-invasive biomarker in disease prognosis evaluation and early diagnosis is prospected.
维普
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