Research progress on biological function and clinical application of microRNA-142
This article summarizes the biological functions of miR-142 and its clinical application,and points out that miR-142 regulates the biological functions of cell proliferation,autophagy,apoptosis,migration and invasion through PI3K/AKT/mTOR,MAPK/ERK and NF-κB signaling pathways.The signaling pathways regulated in different diseases vary according to their activity types,targeting specific proteins and molecules,thereby regulating cell proliferation,autophagy,apoptosis,migration and invasion.The expression level of miR-142 is affected by the abnormal methylation of CpG islands in its promoter region.MiR-142 can affect the sensitivity of chemotherapeutic drugs in a variety of malignant tumors.On this basis,the value of miR-142 as a potential therapeutic target for molecular medicine,is discussed in depth,and the possibility of miR-142 as a potential therapeutic target is revealed.The application prospect of miR-142 as a non-invasive biomarker in disease prognosis evaluation and early diagnosis is prospected.
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