磷酸戊糖途径抑制感光细胞凋亡及分子机制的研究进展
Research progress on the inhibition of photoreceptor cell apoptosis by the pentose phosphate pathway and its molecular mechanism
韩思杨 1孙晓东1
作者信息
- 1. 上海交通大学附属第一人民医院眼科 国家眼部疾病临床医学研究中心 上海市眼部疾病临床医学研究中心 上海市眼底病重点实验室 上海眼视觉与光医学工程技术研究中心 上海市眼科疾病精准诊疗工程技术研究中心,上海 200080
- 折叠
摘要
感光细胞是一种特殊的神经上皮细胞,在视觉信号的产生和传导中具有重要作用,其主要通过大量摄取葡萄糖进行糖代谢以满足生理需求.而感光细胞凋亡,则是视网膜疾病导致患者盲的共同原因,该过程伴有氧化应激和合成代谢的改变.近期研究发现,糖代谢的重要分支——磷酸戊糖途径,在上述病理发展中起重要作用.其产物烟酰胺腺嘌呤二核苷酸磷酸(NADPH)作为感光细胞中重要的供氢体,参与物质合成代谢,对抗氧化应激,进而抑制感光细胞的凋亡.本文将从代谢活动和分子通路的角度,针对磷酸戊糖途径抑制感光细胞凋亡的作用机制进行综述,以期为临床科研工作提供参考.
Abstract
Photoreceptor cells are a special type of neuroepithelial cells,which play an important role in the generation and transmission of visual signals.They mainly meet the physiological needs by ingesting a large amount of glucose for glucose metabolism.Photoreceptor cell apoptosis is a common cause of blindness in patients with retinal diseases,which is accompanied by changes in oxidative stress and anabolism.Recent studies have found that pentose phosphate pathway,an important branch of glucose metabolism,plays an essential role in the development of the above-mentioned pathology.Its product,nicotinamide adenine dinucleotide phosphate(NADPH),as a crucial hydrogen donor in photoreceptor cells,participates in substance synthesis and metabolism,resists oxidative stress,and then inhibits apoptosis of photoreceptor cells.This review summarized the mechanism of pentose phosphate pathway in inhibiting photoreceptor cell apoptosis from the perspective of view of metabolic activity and molecular pathway to provide reference for clinical scientific research.
关键词
感光细胞/凋亡/磷酸戊糖途径/氧化应激/脂质代谢/综述Key words
Photoreceptor cells/Apoptosis/Pentose phosphate pathway/Oxidative stress/Lipid metabolism/Review引用本文复制引用
基金项目
国家自然科学基金重点项目(81730026)
出版年
2024
NETL
NSTL
维普
万方数据