衰老与年龄相关性黄斑变性
Aging and age-related macular degeneration
雷艺 1颜华1
作者信息
- 1. 天津医科大学总医院眼科 天津医科大学,天津 300052
- 折叠
摘要
随着人口老龄化,与衰老相关的眼病发病率也逐渐升高,尤其是年龄相关性黄斑变性.近年来在年龄相关性黄斑变性(AMD)的治疗方面取得了一定的进展,但其仍然是老年人视力障碍和盲的主要原因之一.目前,大量研究认为AMD主要由衰老和炎症两方面因素共同作用造成的.尽管更多的研究聚焦于炎症对AMD的作用,衰老作为其重要相关因素,也同样值得我们深入探究.本文就衰老造成的物质堆积、吞噬功能异常、线粒体功能异常和氧化应激损伤等与AMD的发生和发展的密切关系进行综述,以期提高临床医生对AMD的认知.
Abstract
With the aging of the population in modern society,the incidence of age-related diseases increases gradually,especially the age-related macular degeneration(AMD).Despite advances in treatment in recent years,AMD remains one of the leading causes of blindness and visual impairment in the elderly.At present,people tend to think that AMD is caused by the combination of aging and inflammation,which also contribute to the occurrence and development of many other age-related diseases.Although more studies have focused on the role of inflammation in AMD,aging,as an important correlate,is also deserves in-depth investigation.This article reviewed the close relationship between substance accumulation,abnormal phagocytosis,abnormal mitochondrial function and oxidative stress damage caused by aging and the occurrence and development of AMD,with a view to improving clinicians'knowledge of AMD.
关键词
衰老/年龄相关性黄斑变性/Bruch膜/氧化应激Key words
Aging/Age-related macular degeneration/Bruch membrane/Oxidative stress引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据