年龄相关性黄斑变性中RPE细胞程序性死亡的研究进展
Progress in programmed cell death of RPE cells in age-related macular degeneration
景清荷 1孔虹雨 1赵晨1
作者信息
- 1. 复旦大学附属眼耳鼻喉科医院眼科,上海 200031
- 折叠
摘要
年龄相关性黄斑变性(AMD)是全世界老年人致盲的主要原因,其特征是光感受器、视网膜色素上皮(RPE)、Bruch膜及脉络膜毛细血管复合体的功能退化.RPE细胞功能损害是导致临床相关AMD变化的分子途径中的早期及关键事件.程序性死亡(PCD)在应激反应、体内平衡调节和疾病中起着重要作用.各种研究发现,凋亡、焦亡、坏死性凋亡以及铁死亡均可能参与RPE细胞的程序性死亡,进而促进AMD的发生和发展.各种死亡通路间可能存在交互或协同作用.本文就RPE细胞凋亡、焦亡、坏死性凋亡、铁死亡及其相关机制在AMD发生发展中的作用的研究现状进行综述,为AMD的防治提供新思路.
Abstract
Age-related macular degeneration(AMD)is a leading cause of blindness in the elderly worldwide and is characterized by degeneration of the photoreceptor,retinal pigment epithelium,Bruch membrane and choriocapillaris complex.Impairment of RPE cell function is an early and critical event in the molecular pathways leading to clinically relevant AMD changes.Programmed cell death(PCD)plays an important role in response to stress and regulation of homeostasis and disease.In recent years,multiple studies have shown that apoptosis,pyroptosis,necroptosis and ferroptosis are likely involved in RPE cell PCD and correlate with the onset and development of AMD.There may be interaction or synergy between the various death pathways.This article reviewed the pathogenic mechanism of apoptosis,pyroptosis,necroptosis and ferroptosis in retinal pigment epithelial cell and their research progress in AMD,which might provide new approaches for the prevention and treatment of AMD.
关键词
年龄相关性黄斑变性/视网膜色素上皮/程序性细胞死亡/干扰素Key words
Age-related macular degeneration/Retinal pigment epithelium/Programmed cell death/Interferon引用本文复制引用
基金项目
国家自然科学基金(81730025)
上海市优秀学术带头人计划(18XD1401000)
出版年
2024
NETL
NSTL
维普
万方数据