Modelling Study on the Regulation of Insulin on Glucose Metabolism Mediated by Cyclin D1
Insulin regulates glucose metabolism through Cyclin D1,which has been lack of systematic and complete understanding.Based on Hill dynamics and Michaelis-Menten equation.In this paper,we built a theoretical model to study the regulatory effect of Insulin mediated by Cyclin D1 on glucose metabolism.We found that Insulin inhibited GSK3 by stimulating AKT and promoted the expression of Cyclin D1.The formed Cyclin D1-CDK4 complex can change the activity and phosphorylation level of GCN5,real-ize the inhibition and regulation of the enzyme PCK1,which is an important participant in glucose metabolism,and then regulate glu-cose metabolism.The theoretical results are consistent with the experiment.It further systematically and completely revealing the regu-latory mechanism of insulin on glucose metabolism mediated by Cyclin D1,confirming the regulatory effect of Cyclin D1 on glu-cose metabolism,and providing theoretical basis for the design of the treatment plan for blocking the pathological changes caused by the abnormality of Cyclin D1.
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