Modeling the Crosstalk Dynamics between YAP and Notch Signals
Based on Hill dynamics and Michaelis-Menten equation,a relatively complete theoretical model was established to study the crosstalk dynamics between YAP and Notch signals.We found that YAP activation can induce an increase in Notch expression.The enhanced Notch signal indirectly leads to a decrease in YAP expression,revealing the crosstalk interaction between YAP/Notch regulatory signals.Based on the results of this model,it can be predicted that when there is crosstalk between YAP and Notch signals,YAP will induce Notch signal anomalies.Similarly,abnormal Notch signaling can also affect the YAP signaling pathway.In normal cellular processes,YAP and Notch dynamically synergistically regulate cell processes.This result can be used to predict the presence of lesions triggered by abnormal YAP and Notch signaling.The theoretical results obtained in this article are consistent with experimental observations,further revealing the physical mechanism of crosstalk between YAP and Notch signals,and providing valuable reference for further research on the crosstalk regulation of YAP and Notch signals in the future.
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