Network Pharmacologic Analysis and Experimental Verification of Volatile Oil Components from Mastic in Treatment of Inflammatory
In this study,the key targets and mechanisms of Mastic gum oil(MGO)in the treatment of inflammation were explored based on network pharmacology and cell experiments.The chemical components and related targets of MGO were obtained by gas chromatography-mass spectrometry,traditional Chinese medicine system pharmacology(TCMSP)database and literature review,and the component-target-pathway network was constructed to analyze the potential targets and pathways of MGO anti-inflammation,and the protein-protein interaction(PPI)network was drawn.Two abundant monoterpenes,6,6-dimethyl-4-methylidenebicyclo[3.1.1]heptane-2α,3β-diol and 6,6-dimethyl-4-hydroxy[3.1.1]hept-2-ene-2-carboxylic acid were isolated and identified from MGO by column chromatography and modern spectroscopic techniques.It showed comparable activity to the positive control dexamethasone in the cell inflammation model stimulated by LPS.In this paper,the anti-inflammatory effect of MGO was studied based on network pharmacology and molecular docking technology,which provided theoretical support for clarifying the pharmacodynamic material basis and molecular mechanism of Mastic in clinical treatment of inflammation.
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维普
