The Therapeutic Effect of Hypofractionated Conformal Intensity Modulated Radiotherapy on Non-small Cell Lung Cancer Patients
Objective The therapeutic effect of hypofractionated conformal intensity modulated radiotherapy on non-small cell lung cancer(NSCLC)patients was explored.Methods With the selection of 86 NSCLC patients admitted to the hospital from October 2021 to October 2022 as the study subjects,they were randomly divided into the control group and the experimental group used a random number table method,with 43 patients in each group.With the control group received conventional fractionated conformal intensity modulated radiation therapy,and the experimental group received hypofractionated conformal intensity modulated radiotherapy,the total effective rate of treatment,levels of tumor markers[carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)],levels of immune function indicators(CD3+,CD4+,CD8+),and incidence of complications(nausea and vomiting,bone marrow suppression,anemia,radiation pneumonia)were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of CA125,CEA,CD3+,CD4+,and CD8+ between the two groups(P>0.05);After treatment,the levels of CA125,CEA,CD3+,and CD4+ in both groups were lower than before treatment in the same group,while the levels of CD8+ were higher than before treatment in the same group.Moreover,the levels of CA125,CEA,CD3+,and CD4+ in the experimental group were lower than those in the control group,and the levels of CD8+ were higher than those in the control group,with statistical significance(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The therapeutic effect of hypofractionated conformal intensity modulated radiotherapy on NSCLC patients is better than that of conventional fractionated conformal intensity modulated radiation therapy,which can reduce the level of tumor markers and improve immune function and without increasing the risk of complications.
Hypofractionated conformal intensity modulated radiotherapyNon-small cell lung cancerTumor markersImmunologic function
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维普
