The Effect of Medical Temperature Controller on Neurobehavioral and Neurological Injury Indicators in Newborns with Hypoxic-Ischemic Encephalopathy
Objective To explore the effects of medical temperature controllers on neurobehavioral and neuroinjury markers in newborns with hypoxic-ischemic encephalopathy(HIE).Methods With the selection of 74 newborns with HIE admitted to Taizhou Hospital of Zhejiang Province from July 2019 to October 2021 as the research subjects,they were randomly divided into two groups,by using the random number table method,with 37 cases in each group.the control group received routine treatments such as oxygen inhalation,lowering intracranial pressure,sedation,and stabilizing blood sugar,blood pressure,and internal environment,and the experimental group received additional medical temperature control devices in addition to the control group,both groups were followed up until 28 days after birth.The recovery time of consciousness,reflexes,and muscle tone between the two groups,as well as the neurological behavior before treatment and 28 days after birth[evaluated by using the Neonatal Behavioral Neurological Assessment(NBNA)],the degree of developmental defects[evaluated by using the Gesell Developmental Assessment Scale],and serum levels of nerve injury markers[neuron specific enolase(NSE)and myelin basic protein(MBP)]were compared,and the incidence of neurological sequelae within one year in both groups was statistically analyzed.Results The recovery time of consciousness,reflex,and muscle tone in the experimental group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After 28 days of birth,the NBNA and Gesell scores of both groups were higher than before treatment,and the serum NSE and MBP levels were lower than before treatment.In addition,the NBNA and Gesell scores of the experimental group were higher than those of the control group,and the serum NSE and MBP levels were lower than those of the control group,with statistical significance(P<0.05).The incidence of neurological sequelae within one year in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of medical temperature controllers in HIE newborns not only accelerates the recovery of consciousness,reflexes,and muscle tone,but also improves neurological behavior,reduces the degree of developmental defects,and reduces the occurrence of neurological sequelae,which is closely related to its ability to reduce NSE and MBP levels,promote neural recovery and regeneration.
Medical temperature controllerHypoxic-ischemic encephalopa thyNewbornsNeurobehaviorThe degree of developmental defectsNeurological injury markersNeurological sequelae
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