The Correlation Between Peripheral Blood Interleukin-18, Matrix Metalloproteinase-9 Levels and Delayed Intracranial Hematoma in Patients with Traumatic Brain Injury
Objective To explore the correlation between peripheral blood levels of interleukin-18(IL-18)and matrix metalloproteinase-9(MMP-9)and delayed intracranial hematoma(DTIH)in patients with traumatic brain injury(TBI).Methods A total 88 TBI patients admitted to the hospital from April 2021 to August 2022 were selected as the study subjects.After treatment,all patients underwent 2 or more head CT scans.According to whether DTIH occurred after treatment,they were divided into DTIH group(45 cases)and non DTIH group(43 cases).General information of the patients was collected,and IL-18 and MMP-9 were detected by enzyme-linked immunosorbent assay.Univariate analysis and logistic multiple regression analysis were used to identify the factors affecting the occurrence of DTIH.Results The diastolic blood pressure,plasma thrombin time(TT),IL-18,and MMP-9 in the DTIH group were higher than those in the non DTIH group,while the Glasgow Coma Index(GCS)score was lower than that in the non DTIH group,with statistical significance(P<0.05).The results of multiple factor analysis suggest that IL-18(β =0.294,OR=1.342,95%CI=1.044-1.724)and MMP-9(β =0.298,OR=1.347,95%CI=1.093-1.659)was a risk factor for DTIH in TBI patients(P<0.05).Conclusion The abnormal expression of IL-18 and MMP-9 is related to the occurrence of DTIH in patients after treatment,and both are risk factors for DTIH in TBI patients.
万方数据
维普
