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不同密度覆盖物对放射治疗表浅剂量的影响

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目的 探究放射治疗过程中不同密度覆盖物对表浅剂量的影响.方法 应用蒙特卡洛程序EGSnrc模拟直线加速器的6 MV光子束,并在加速器射束中心且源皮距100 cm处设置 30 cm×30 cm×30 cm的水模体对加速器射束的百分剂量深度准确性进行验证;然后构建模拟人体的组织模体(尺寸为 30 cm×30 cm×30 cm),并在组织模体表面覆盖 5 mm厚的放射治疗常见覆盖物(石蜡、湿纱布、商用补偿膜Bolus及热塑膜),模拟加速器光子束照射模体过程,收集组织模体表面下射束中心轴百分深度剂量进行分析.为排除增加0.5 cm建成区域带来的影响,在组织模体表面覆盖与组织模体相同材质的覆盖物,收集相同条件下的照射结果并与上述结果进行比较.结果 EGSnrc模拟的 6 MV射束在水模体中的百分深度剂量与加速器实际测量值的差异<1%;与无覆盖物相比,4 种不同密度的覆盖物均能增加一定的模体表浅剂量,且剂量增幅随模体深度增加逐渐降低;不同覆盖物下组织模体的剂量增幅最大处均为组织模体表面,石蜡、湿纱布、商用补偿膜Bolus及热塑膜产生的增加幅度分别为36.45%、42.42%、43.23%及54.79%,剂量增幅随覆盖物密度增大呈现递增趋势,最大剂量点处剂量分别变化-0.49%、-0.59%、-0.65%及-1.15%;在相同深度且模体表面下深度<1 cm时,不同覆盖物的深度剂量与材料密度具有显著相关性(P<0.05);与组织模体密度比较,覆盖物密度差异越大对组织模体剂量的影响越大,其中与组织模体密度差异最大的热塑膜剂量增幅为 7.54%,密度差异最小的水增幅约为 1%.结论 不同密度的表面覆盖物均会增加组织模体表浅剂量,且剂量增幅随深度增加逐渐降低;不同覆盖物的深度剂量与覆盖物密度显著相关;不同材料覆盖物对表浅剂量的影响存在差异,覆盖物与组织模体密度差异越大对接触面表浅剂量的影响越大,但常见表皮覆盖物的相对密度差异不大,因此剂量影响主要来源于覆盖物造成的可预见建成区深度的增加.
The Effect of Different Density Coverings on the Superficial
Objective To investigate the effect of different density coverings on superficial dose during radiation therapy.Methods With the application of Monte Carlo program(EGSnrc)to simulate the accelerator 6 MV photon beam,at the center of the accelerator beam and the source skin distance 100 cm,30 cm×30 cm×30 cm water phantom was set to verify the accuracy of the percentage dose depth of the accelerator beam;Afterwards,with the construction of a tissue phantom simulating the human body(with a size of 30 cm×30 cm×30 cm),common covering materials(paraffin,wet gauze,commercial compensation film Bolus,and thermoplastic film)for radiation therapy with a thickness of 5 mm were covered on the surface of the tissue phantom.Meanwhile,with the simulation of the process of accelerator photon beam irradiation on the phantom,the percentage depth dose of the beam center axis below the surface of the tissue mold was collected and analyzed.To eliminate the impact of adding 0.5 cm of built-up area,the covering material with the same material for the tissue phantom was covered on the surface of the tissue phantom,and the irradiation results under the same conditions were collected and compared with the above results.Results The difference between the percentage depth dose of the 6 MV beam simulated by EGSnrc in the water model and the actual measured value of the accelerator was less than 1%;Compared with no cover,all four cover with different densities could increase the superficial dose of the phantom to varying degrees,and the magnitude of dose increase gradually decreased with the increase of phantom depth;Under different coverings,the maximum dose increase was at the surface of the tissue phantom.The magnitude of increase for paraffin,wet gauze,commercial compensation film Bolus and thermoplastic film were 36.45%,42.42%,43.23% and 54.79%,respectively.The magnitude of increase in dose showed a decreasing trend with the increase in covering density,the dose at the maximum dose point varied by-0.49%,-0.59%,-0.65%,and-1.15%,respectively;At the same depth and under the mold surface depth<1 cm,the depth dose of different coverings was significantly correlated with the material density(P<0.05).Compared with the density of the tissue phantom,as the difference in coverage density increased,the dose effect on the tissue phantom became greater.The magnitude of dose increase of the thermoplastic film with the largest density difference from the tissue model was 7.54%,and the magnitude of increase of water with the smallest density difference was about 1%.Conclusions The surface coverings with different densities increase the superficial dose of the tissue mold to different degrees,and the influence decreases with the increase of depth;The depth dose of different coverings is significantly correlated with its density;There are differences in the impact of different material coverings on superficial dose.The larger the density difference between the cover and the tissue phantom has a greater impact on the shallow dose of the contact surface.However,for common epidermal coverings,there was little difference in relative density,and the dose effect was mainly due to the predictable increase in built-up area depth caused by the coverings.

EGSnrcMonte Carlo programDensityCovering materialSuperficial dosePercentage depth dose

高雅、王岩、曾志鹏、陈国祥

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浏阳市人民医院 (湖南长沙 410300)

EGSnrc 蒙特卡洛程序 密度 覆盖物 表浅剂量 百分深度剂量

2024

医疗装备
国家食品药品监督管理局北京医疗器械质量监督检验中心 北京市医疗器械检验所

医疗装备

影响因子:0.339
ISSN:1002-2376
年,卷(期):2024.37(6)
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