摘要
目的 探讨不同配准方法在食管癌图像引导放射治疗(IGRT)中的应用效果.方法 选取 2022 年 8 月至 2023 年 8 月于医院接受IGRT的 24 例食管癌患者,均于治疗前采用X线容积成像(XVI)系统进行锥形束CT(CBCT)扫描,且分别采用 3 种方法(自动灰度配准、自动骨性配准和手动配准)进行图像配准.比较不同配准方法的配准结果和耗时;以手动配准结果为摆位误差标准,比较自动灰度配准、自动骨性配准排除摆位误差后的差异.结果 3种方法左右(x)方向的配准结果分别为-1.05(-3.75,0.40)、-1.00(-3.08,0.23)、-0.90(-2.88,0.33)mm,头脚(y)方向的配准结果分别为(-0.78±3.50)、(0.51±3.95)、(0.64±3.97)mm,前后(z)方向的配准结果分别为-2.25(-6.15,0.40)、-3.40(-5.34,0.60)、-3.20(-5.33,0.70)mm,差异均无统计学意义(P>0.05);3 种方法的配准耗时分别为(2.56±0.42)、(2.17±0.58)、(52.15±14.51)s,差异有统计学意义(P<0.05).排除摆位误差后,自动灰度配准与自动骨性配准在y和z方向的偏差值比较,差异有统计学意义(P<0.05).结论 自动灰度配准、自动骨性配准和手动配准均可用于食管癌IGRT的图像配准,权衡精度和时间成本后,推荐使用自动骨性配准.
Abstract
Objective To explore the application effects of different registration methods in image guided radiotherapy(IGRT)for esophageal cancer.Methods With the selection of 24 esophageal cancer patients who underwent IGRT in the hospital from August 2022 to August 2023,all patients underwent cone beam computed tomography(CBCT)scans using X-ray volume imaging(XVI)system before treatment.In addition,three methods(automatic grayscale registration,automatic bone registration,and manual registration)were used for image registration,respectively.The registration results and time consumption of different registration methods were compared;With the manual registration results as the standard for positioning error,the differences between automatic grayscale registration and automatic bone registration after excluding positioning errors were compared.Results The registration results of the three methods in the left and right(x)directions are-1.05(-3.75,0.40),-1.00(-3.08,0.23),-0.90(-2.88,0.33)mm,and the registration results in the head and foot(y)directions are(-0.78±3.50),(0.51±3.95),and(0.64±3.97)mm,respectively;The registration results in the front and back(z)directions were-2.25(-6.15,0.40),-3.40(-5.34,0.60),and-3.20(-5.33,0.70)mm,respectively,with no statistically significant differences(P>0.05);The registration times of the three methods were(2.56±0.42),(2.17±0.58),and(52.15±14.51)s,respectively,with statistically significant differences(P<0.05).After excluding positioning errors,there was a statistically significant difference in the deviation values between automatic grayscale registration and automatic bone registration in the y and z directions(P<0.05).Conclusions Automatic grayscale registration,automatic bone registration,and manual registration can all be used for image registration of esophageal cancer IGRT.After weighing accuracy and time cost,it is recommended to use automatic bone registration.
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