Analysis of Pathogenic Bacteria and Drug Resistance in Elderly Patients with Severe Pneumonia
Objective To analyze the characteristics of pathogenic bacteria in elderly patients with severe pneumonia and to provide a basis for clinical anti-infection.Methods Retrospective analysis of the clinical data from 113 elderly patients with severe pneumonia hospitalized in hospitals from 2020 to 2022,the results of pathogen culture were statistically analyzed for drug resistance analysis.Results 163 strains of pathogenic bacteria were isolated from 113 samples of elderly severe pneumonia patients,including 126 strains of Gram-negative bacteria,26 strains of Gram-positive bacteria,and 11 strains of fungi.Gram-negative bacteria mainly included Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,Stenotrophomonas maltophilia,Escherichia coli,and Enterobacter cloacae.Gram-positive bacteria were mainly Staphylococcus aureus,Staphylococcus aureus,and Staphylococcus hemolysis.Fungi were mainly Candida albicans and Candida tropicalis.Klebsiella pneumoniae has high resistance to ampicillin and cefotaxime,but low resistance to amikacin and compound sulfamethoxazole.Acinetobacter baumannii has low resistance to minocycline and high resistance to other antibiotics.Pseudomonas aeruginosa has high resistance to amoxicillin-clavulanic acid,cefuroxime sodium,and compound sulfamethoxazole,but low resistance to ceftazidime,amikacin,and tobramycin.Conclusions With Gram-negative bacteria as the main pathogen of infection in elderly patients with severe pneumonia,Klebsiella pneumoniae,Acinetobacter baumannii,and Pseudomonas aeruginosa account for a large proportion and have a high resistance rate.
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