经导管动脉化疗栓塞术联合微波消融治疗原发性肝细胞癌患者疗效观察
Observation on the therapeutic effect of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of primary hepatocellular carcinoma patients
聂春生 1王玉峰 1李士杰 1侯英文 1刘家1
作者信息
- 1. 150081 哈尔滨医科大学附属肿瘤医院介入科
- 折叠
摘要
目的 观察经导管动脉化疗栓塞术(TACE)联合微波消融治疗原发性肝细胞癌(HCC)对患者血清肿瘤标志物、T淋巴细胞亚群的影响.方法 收集2018 年10 月—2021 年12 月哈尔滨医科大学附属肿瘤医院介入科收治的原发性HCC患者104 例临床资料,随机分为TACE组52 例(TACE治疗)、联合组52 例(TACE +微波消融治疗),评估术后1 个月疗效,比较治疗前后2 组患者肝功能指标、血清肿瘤标志物、T淋巴细胞亚群,统计患者并发症发生率.结果 联合组总有效率为86.5%,高于TACE组的69.2%(χ2/P =4.522/0.033);治疗后1 个月联合组AST、ALT水平低于TACE组(t =10.473、8.602,P均<0.001);AFP水平低于TACE组(t =11.724,P<0.001);CD4+、CD4+/CD8+高于TACE组,CD8+低于TACE组(t =3.913、5.460、5.586,P均<0.001);2 组并发症发生率比较差异无统计学意义(P>0.05).结论 原发性HCC患者接受TACE联合微波消融治疗可显著下调其血清肿瘤标志物水平,改善肝功能及免疫功能,提升整体疗效.
Abstract
Objective To observe the effects of transcatheter arterial chemoembolization(TACE)combined with microwave ablation on serum tumor markers and T lymphocyte subsets in patients with primary hepatocellular carcinoma(HCC).Methods Collect clinical data of 104 patients with primary HCC admitted to the Interventional Department of Harbin Medical University Affiliated Cancer Hospital from October 2018 to December 2021.They were randomly divided into a TA-CE group of 52 cases(TACE treatment)and a combination group of 52 cases(TACE+microwave ablation treatment).Evalu-ate the efficacy one month after surgery,compare the liver function indicators,serum tumor markers,and T lymphocyte sub-sets of the two groups before and after treatment,and calculate the incidence of patient complications.Results The total effective rate of the combined group was 86.5%,higher than the 69.2%of the TACE group(χ2/P=4.522/0.033);After one month of treatment,the AST and ALT levels in the combination group were lower than those in the TACE group(t=10.473,8.602,P<0.001);The AFP level in the combination group was lower than that in the TACEgroup(t=11.724,P<0.001);The CD4+and CD4+/CD8+in the combined group were higher than those in the TACE group,while CD8 +was lower than those in the TACE group(t=3.913,5.460,5.586,all P<0.001);There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Primary HCC patients receiving TACE combined with micro-wave ablation treatment can significantly reduce their serum tumor marker levels,improve liver and immune function,and en-hance overall efficacy.
关键词
肝细胞癌,原发性/导管动脉化疗栓塞术/微波消融/肿瘤标志物/T淋巴亚群Key words
Hepatocellular carcinoma,primary/Catheter arterial chemoembolization/Microwave ablation/Tumor markers/T lymphoid subsets引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据