NRG1、HER3在前列腺癌组织中的表达及其与临床病理特征和预后的关系
The expression of NRG1 and HER3 in prostate cancer tissue and their relationship with clinical pathological features and prognosis
王潇然 1陆巍 1于欣 2王永杰 2王勇 1廉吉虎 1李震霄 2宋海涛2
作者信息
- 1. 130021 长春,吉林省人民医院泌尿外科
- 2. 130021 长春,吉林省人民医院重症医学科
- 折叠
摘要
目的 研究前列腺癌(PC)组织中神经调节蛋白1(NRG1)、人表皮生长因子受体3(HER3)表达与临床病理特征及预后的关系.方法 选取2015 年2 月—2020 年2 月吉林省人民医院泌尿外科诊治PC患者96 例,免疫组织化学检测组织中NRG1、HER3 表达;Kaplan-Meier曲线(Log-Rank检验)比较不同NRG1、HER3 表达对PC患者预后的影响;COX回归分析PC患者预后的影响因素.结果 PC癌组织中NRG1、HER3 阳性率分别为 78.13%(75/96)、75.00%(72/96),高于癌旁组织 6.25%(6/96)、8.33%(8/96)(χ2/P =101.670/<0.001,87.771/<0.001).TNM分期Ⅲ期、Gleason评分>7 分及术前PSA水平≥20 μg/L患者癌组织中NRG1、HER3 阳性率大于TNM分期Ⅰ～Ⅱ期、Gleason评分≤7 分及术前PSA水平<20 μg/L(χ2/P =6.181/0.013,8.533/0.003;7.731/0.005,6.769/0.009;6.508/0.011,7.376/0.007).NRG1 阳性组、HER3 阳性组3 年累积无进展生存率分别低于NRG1 阴性组、HER3 阴性组(χ2/P =4.267/0.039,5.499/0.019).TNM分期Ⅲ期、Gleason评分>7 分、术前PSA≥20 μg/L、NRG1 阳性,HER3阳性是影响PC患者预后的独立危险因素[OR(95%CI)=1.448(1.118～1.875),1.401(1.138～1.724),1.353(1.059～1.728),1.338(1.057～1.692),1.293(1.014～1.649)].结论 PC癌组织中NRG1、HER3 表达升高,与PC不良临床病理特征相关,是新的评估PC预后的肿瘤标志物.
Abstract
Objective To investigate the relationship between the expression of neuroregulatory protein 1(NRG1)and human epidermal growth factor receptor 3(HER3)in prostate cancer(PC)tissue and their clinical pathological character-istics and prognosis.Method Ninety-six PC patients diagnosed and treated in the urology department of Jilin Provincial People's Hospital from February 2015 to February 2020 were selected,and the expression of NRG1 and HER3 in the tissues was detected by immunohistochemistry;Kaplan Meier curve(Log Rank test)was used to compare the impact of different NRG1 and HER3 expressions on the prognosis of PC patients;COX regression analysis of prognostic factors in PC patients.Results The positive rates of NRG1 and HER3 in PC cancer tissues were 78.13％(75/96)and 75.00％(72/96),respectively,which were higher than those in adjacent tissues by 6.25％(6/96)and 8.33％(8/96)(χ2/P=101.670/<0.001,87.771/<0.001).TNM stage Ⅲ,Gleason score>7,and preoperative PSA level≥20 μ The positive rates of NRG1 and HER3 in cancer tis-sues of g/Lpatients werehigherthanthosein TNMstagingstages Ⅰ- Ⅱ,Gleasonscore≤7,andpreoperative PSAlevel<20 μ G/L(χ2/P=6.181/0.013,8.533/0.003;7.731/0.005,6.769/0.009;6.508/0.011,7.376/0.007).The 3-year cumulative progression free survival rates of the NRG1 positive group and HER3 positive group were lower than those of the NRG1 negative group and HER3 negative group,respectively(χ2/P=4.267/0.039,5.499/0.019).TNM stage Ⅲ,Gleason score>7,preoperative PSA≥20 μ G/L,NRG1 positivity,and HER3 positivity are independent risk factors affecting the prognosis of PC patients[OR(95％CI)=1.448(1.118-1.875),1.401(1.138-1.724),1.353(1.059-1.728),1.338(1.057-1.692),1.293(1.014-1.649)].Conclu-sion The increased expression of NRG1 and HER3 in PC cancer tissue is associated with adverse clinical and pathological features of PC,and is a new tumor marker for evaluating the prognosis of PC.
关键词
前列腺癌/神经调节蛋白1/人表皮生长因子受体3/预后Key words
Prostate cancer/Neuromodulation protein 1/Human Epidermal growth factor receptor 3/Prognosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据