结直肠锯齿状息肉发病机制及微小RNA作用的研究进展
Research progress on the pathogenesis of colorectal serrated polyps and the role of microRNAs
杨凯惠 1马瑞军 1汪嵘1
作者信息
- 1. 030012 太原,山西医科大学第五临床医学院
- 折叠
摘要
锯齿状息肉(SP)具有一定的恶变潜能,通过独特的锯齿状癌变途径,导致了15%～30%结直肠癌的发生.微小RNA(microRNA或miRNA)是一类小的非编码RNA,与肿瘤的发生发展有关.有研究发现,miRNA在锯齿状息肉(尤其是无蒂锯齿状病变)中存在异常表达,可能参与了结直肠癌的进展.文章对锯齿状息肉的发病机制及miRNA在不同类型锯齿状息肉中的表达差异进行综述.
Abstract
Serrated polyps(SP)have certain malignant potential,resulting in approximately 15%to 30%of colorec-tal cancers through a unique serrated carcinogenic pathway.MicroRNAs(microRNAs or miRNAs)are a class of small,non-coding RNAs that are associated with the development of tumors.Studies have found that miRNA is abnormally expressed in serrated polyps(especially sessile serrated lesions),which may be involved in the progression of colorectal cancer.The article mainly summarizes the pathogenesis of jagged polyps and the differences in miRNA expression in different types of jagged polyps.
关键词
结直肠癌/锯齿状息肉/临床特征/发病机制/微小RNAKey words
Colorectal cancer/Serrated polyps/Clinical features/Pathogenesis/MicroRNA引用本文复制引用
基金项目
山西省卫生健康委面上项目(202203021221259)
出版年
2024
国家科技期刊平台
NSTL
万方数据